Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network (Q24301479)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424149%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network (English)

1 reference

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15 January 2020

main subject

cystic fibrosis

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transmembrane protein

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curcumin

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Keratin 18

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GOA release 2020-03-11

author

Frédéric Becq

6

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15 January 2020

7

Aleksander Edelman

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15 January 2020

author name string

Joanna Lipecka

1

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15 January 2020

Caroline Norez

2

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15 January 2020

Noura Bensalem

3

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15 January 2020

Maryvonne Baudouin-Legros

4

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15 January 2020

Gabrielle Planelles

5

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15 January 2020

Noélie Davezac

8

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15 January 2020

language of work or name

English

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publication date

19 January 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424149%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacology and Experimental Therapeutics

15 January 2020

published in

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15 January 2020

volume

317

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15 January 2020

page(s)

500-505

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15 January 2020

issue

2

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Recent studies on the biofunctions and biotransformations of curcumin

15 January 2020

cites work

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Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

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7 January 2021

Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane

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Pharmacological induction of CFTR function in patients with cystic fibrosis: mutation-specific therapy.

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Implications of intermediate filament protein phosphorylation

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

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Degradation of CFTR by the ubiquitin-proteasome pathway

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Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells

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Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein

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7 January 2021

Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders.

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Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells

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Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

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Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells

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Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation

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Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.

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7 January 2021

Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator

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7 January 2021

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

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7 January 2021

Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs

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7 January 2021

Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization

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7 January 2021

The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells

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7 January 2021

COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments

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7 January 2021

Keratins modulate colonocyte electrolyte transport via protein mistargeting

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Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

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7 January 2021

The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton

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7 January 2021

Curcumin, a medicinal herbal compound capable of inducing the heat shock response

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7 January 2021

Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line

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7 January 2021

Intermediate filaments and vesicular membrane traffic: the odd couple's first dance?

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7 January 2021

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

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7 January 2021

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