MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis (Q24301309)

DNA damage response, signal transduction by p53 class mediator

GOA release 2020-03-11

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GOA release 2020-03-11

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9

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Fabiola Moretti

11

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Francesca Mancini

1

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Francesca Gentiletti

2

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Simona Giglio

4

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author name string

Marco D'Angelo

3

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Simona Nanni

5

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Carmen D'Angelo

6

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Antonella Farsetti

7

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Gennaro Citro

8

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Alfredo Pontecorvi

Journal of Biological Chemistry

10

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language of work or name

English

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publication date

27 February 2004

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published in

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volume

279

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issue

9

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page(s)

8169-80

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cites work

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Regulation of p53 stability

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Regulation of the p53 tumor suppressor protein

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mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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WAF1, a potential mediator of p53 tumor suppression

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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MdmX protects p53 from Mdm2-mediated degradation

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

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Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

21 January 2018

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UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

21 January 2018

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MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

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DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

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DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

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Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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c-Myc target gene specificity is determined by a post-DNAbinding mechanism

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Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

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A simplified system for generating recombinant adenoviruses

21 January 2018

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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A role for p53 in maintaining and establishing the quiescence growth arrest in human cells

21 January 2018

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G1 events and regulation of cell proliferation

21 January 2018

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NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein

21 January 2018

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MDM2 interacts with MDMX through their RING finger domains

21 January 2018

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The cellular response to p53: the decision between life and death

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

21 January 2018

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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

21 January 2018

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p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

MDM2 and MDMX bind and stabilize the p53-related protein p73

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

Regulation and activation of p53 and its family members

21 January 2018

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Mechanisms of switching on p53: a role for covalent modification?

21 January 2018

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

21 January 2018

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MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

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21 January 2018

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Activation and activities of the p53 tumour suppressor protein

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p53-Mdm2--the affair that never ends

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The p53 and Mdm2 families in cancer.

21 January 2018

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

MDMX inhibits the p300/CBP-mediated acetylation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

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Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

21 January 2018

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7 January 2021

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

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7 January 2021

Expression of transglutaminase 5 in normal and pathologic human epidermis

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

7 January 2021

Hdmx stabilizes Mdm2 and p53

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https://api.crossref.org/works/10.1074%2FJBC.M311793200

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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7 January 2021