RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage (Q24300412)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20173098%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage (English)

1 reference

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18 January 2020

0 references

1 reference

Ring finger and WD repeat domain 3

1 reference

tumor protein p53

1 reference

MDM2/MDM4 family protein binding

1 reference

author

Sung Yun Jung

9

1 reference

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18 January 2020

10

Bert W O'Malley

1 reference

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18 January 2020

author name string

Xiaoyong Fu

1

1 reference

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18 January 2020

Nur Yucer

2

1 reference

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18 January 2020

Shangfeng Liu

3

1 reference

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18 January 2020

Muyang Li

4

1 reference

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18 January 2020

Ping Yi

5

1 reference

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18 January 2020

Jung-Jung Mu

6

1 reference

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18 January 2020

Tao Yang

7

1 reference

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18 January 2020

Jessica Chu

8

1 reference

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18 January 2020

Wei Gu

11

1 reference

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18 January 2020

Jun Qin

12

1 reference

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18 January 2020

Yi Wang

13

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18 January 2020

language of work or name

English

0 references

publication date

19 February 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20173098%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

18 January 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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18 January 2020

volume

107

1 reference

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18 January 2020

issue

10

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18 January 2020

page(s)

4579-4584

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

18 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

19 March 2017

1 reference

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BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

19 March 2017

1 reference

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

19 March 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

6 April 2017

1 reference

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Mammalian G1- and S-phase checkpoints in response to DNA damage

19 March 2017

2 references

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22 April 2017

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Cell cycle checkpoints: preventing an identity crisis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

p53 in health and disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

p53 ubiquitination: Mdm2 and beyond

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

mdm2 expression is induced by wild type p53 activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

The central region of HDM2 provides a second binding site for p53.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

27 September 2017

1 reference

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842028

SnapShot: p53 posttranslational modifications

27 September 2017

1 reference

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A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

21 January 2018

1 reference

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0912094107

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20173098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0912094107

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20173098%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

ADS bibcode

2010PNAS..107.4579F

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20173098%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

20173098

2 references