A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination (Q24299264)

Protein phosphatase 4 regulatory subunit 2

1 reference

Replication protein A2

1 reference

protein-macromolecule adaptor activity

1 reference

author name string

Dong-Hyun Lee

1

0 references

Yunfeng Pan

2

0 references

Shlomo Kanner

3

0 references

Patrick Sung

4

0 references

James A Borowiec

5

0 references

Dipanjan Chowdhury

Nature Structural & Molecular Biology

6

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language of work or name

English

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publication date

March 2010

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published in

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volume

17

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issue

3

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page(s)

365-72

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cites work

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A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

19 March 2017

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RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells

19 March 2017

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

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Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair

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A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres

19 March 2017

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

19 March 2017

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Replication Protein A (RPA): The Eukaryotic SSB

19 March 2017

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Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

19 March 2017

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

19 March 2017

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PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

19 March 2017

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Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin

19 March 2017

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Replication protein A phosphorylation and the cellular response to DNA damage

19 March 2017

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

19 March 2017

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Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

19 March 2017

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A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein

19 March 2017

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ATR: an essential regulator of genome integrity

19 March 2017

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Mechanism of eukaryotic homologous recombination

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A dynamic model for replication protein A (RPA) function in DNA processing pathways

7 April 2017

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Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress

7 April 2017

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Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis

27 September 2017

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miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

27 September 2017

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From promiscuity to precision: protein phosphatases get a makeover

27 September 2017

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Mitotic crisis: the unmasking of a novel role for RPA

27 September 2017

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RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage

27 September 2017

1 reference

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The effect of inhibited replication on DNA migration in the comet assay in relation to cytotoxicity and clastogenicity

27 September 2017

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PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

27 September 2017

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Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair

27 September 2017

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SMK-1/PPH-4.1-mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos

27 September 2017

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RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

27 September 2017

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Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase

27 September 2017

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Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses

27 September 2017

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Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks

27 September 2017

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Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint

27 September 2017

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

27 September 2017

1 reference

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DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

27 September 2017

1 reference

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PP2A: the expected tumor suppressor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057140

Replication protein A (RPA) phosphorylation prevents RPA association with replication centers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057140

RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.

27 September 2017

1 reference

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

27 September 2017

1 reference

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Protein phosphatases regulate DNA-dependent protein kinase activity

27 September 2017

1 reference

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Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057140

Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057140

29 November 2018

Identifiers

DOI

10.1038/NSMB.1769

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3369617

Dimensions Publication ID

1041506627

0 references

Fatcat ID

release_4jolxvi7wncq5k7cxswe3ypmkq

0 references

OpenCitations bibliographic resource ID

3369617

1 reference