Replication protein A2 (Q21115044)

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mammalian protein found in Homo sapiens
  • replication protein A 32 kDa subunit
  • replication protein A 34 kDa subunit
  • RP-A p34
  • RPA2
  • replication protein A2, 32kDa
  • replication factor A protein 2
  • RF-A protein 2
edit
Language Label Description Also known as
English
Replication protein A2
mammalian protein found in Homo sapiens
  • replication protein A 32 kDa subunit
  • replication protein A 34 kDa subunit
  • RP-A p34
  • RPA2
  • replication protein A2, 32kDa
  • replication factor A protein 2
  • RF-A protein 2

Statements

molecular function
protein binding
determination method
IPI
28 references
retrieved
8 April 2019
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
protein binding
determination method
IBA
IPI
29 references
retrieved
1 January 2018
stated in
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IBA
cell component
DNA replication factor A complex
determination method
IDA
IEA
IPI
6 references
retrieved
17 October 2017
stated in
Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IEA
retrieved
17 October 2017
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
17 October 2017
stated in
The primary structure of the 32-kDa subunit of human replication protein A
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
17 October 2017
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
17 October 2017
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15927&geneProductId=UniProtKB:P15927
determination method
IDA
DNA replication factor A complex
determination method
IBA
IDA
IEA
IPI
7 references
retrieved
8 April 2019
stated in
Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IEA
retrieved
8 April 2019
stated in
The primary structure of the 32-kDa subunit of human replication protein A
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
8 April 2019
stated in
Activation of the ATR kinase by the RPA-binding protein ETAA1
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
8 April 2019
stated in
ETAA1 acts at stalled replication forks to maintain genome integrity
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
8 April 2019
stated in
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
GOA
curator
UniProt
UniProt protein ID
P15927
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15927
determination method
IBA
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115044&oldid=2022960559"