Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells (Q24298561)

positive regulation of intrinsic apoptotic signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Alyson J Smith

1

Alyson J

Smith

1 reference

19 October 2023

Haiming Dai

2

Haiming

Dai

1 reference

19 October 2023

Cristina Correia

3

Cristina

Correia

1 reference

19 October 2023

Rie Takahashi

4

Rie

Takahashi

1 reference

19 October 2023

Sun-Hee Lee

5

Sun-Hee

Lee

1 reference

19 October 2023

Ingo Schmitz

6

Ingo

Schmitz

1 reference

19 October 2023

Scott H Kaufmann

7

Scott H

Journal of Biological Chemistry

Kaufmann

1 reference

19 October 2023

language of work or name

English

0 references

publication date

20 May 2011

0 references

published in

0 references

volume

286

0 references

page(s)

17682-92

0 references

issue

20

0 references

cites work

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Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

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The Bcl2 family: regulators of the cellular life-or-death switch

7 April 2017

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

7 April 2017

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

7 April 2017

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Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy

27 September 2017

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Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

27 September 2017

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Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.

27 September 2017

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Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage

27 September 2017

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27 September 2017

The BCL-2 family reunion

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Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes

27 September 2017

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Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma

27 September 2017

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The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.

27 September 2017

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Results of a phase 2 study of bortezomib in patients with relapsed or refractory indolent lymphoma

27 September 2017

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Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

27 September 2017

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27 September 2017

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Phase 2 study of weekly bortezomib in mantle cell and follicular lymphoma

27 September 2017

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Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.

27 September 2017

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A phase II study of bortezomib in patients with MALT lymphoma

27 September 2017

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Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

27 September 2017

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Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.

27 September 2017

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BCL-2 family antagonists for cancer therapy

27 September 2017

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IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis

27 September 2017

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27 September 2017

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Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region

27 September 2017

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Bortezomib in mantle cell lymphoma

27 September 2017

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27 September 2017

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

27 September 2017

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27 September 2017

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Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma

27 September 2017

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27 September 2017

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27 September 2017

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TRAIL therapy in non-small cell lung cancer cells: sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib.

27 September 2017

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27 September 2017

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The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells

27 September 2017

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27 September 2017

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

27 September 2017

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27 September 2017

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Life in the balance: how BH3-only proteins induce apoptosis.

27 September 2017

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

27 September 2017

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Proteasome inhibition in multiple myeloma: therapeutic implication

27 September 2017

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Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

27 September 2017

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Discovery, Development, and clinical applications of bortezomib

27 September 2017

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27 September 2017

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27 September 2017

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Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

27 September 2017

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BH3 domains: intracellular death-ligands critical for initiating apoptosis

27 September 2017

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

27 September 2017

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Apoptosis: a link between cancer genetics and chemotherapy

27 September 2017

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27 September 2017

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

27 September 2017

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27 September 2017

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27 September 2017

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Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression

27 September 2017

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

27 September 2017

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Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

27 September 2017

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Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma

27 September 2017

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The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

27 September 2017

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Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines

27 September 2017

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Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib

27 September 2017

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Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

30 May 2018

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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

30 May 2018

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BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.

30 May 2018

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The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

21 January 2018

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

21 January 2018

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Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

21 January 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.

21 January 2018

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29 November 2018

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Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation

29 November 2018

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