Cell cycle-specific function of Ikaros in human leukemia (Q24298114)

GOA release 2020-03-11

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Zhanjun Li

1

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Chunhua Song

2

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Hongsheng Ouyang

3

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Liangxue Lai

4

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Kimberly J Payne

5

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Sinisa Dovat

Role of Ikaros in T-cell acute lymphoblastic leukemia

6

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language of work or name

English

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publication date

15 July 2012

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published in

Pediatric Blood Cancer

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volume

59

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issue

1

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page(s)

69-76

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cites work

1 reference

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Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia

19 March 2017

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Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

19 March 2017

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The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

19 March 2017

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Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene

19 March 2017

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Multiple hematopoietic defects and delayed globin switching in Ikaros null mice

19 March 2017

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Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis

19 March 2017

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Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

19 March 2017

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Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia

19 March 2017

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Ikaros regulates neutrophil differentiation

19 March 2017

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

19 March 2017

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Ikaros isoforms: The saga continues

7 April 2017

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Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1.

27 September 2017

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Regulator of myeloid differentiation and function: The secret life of Ikaros

27 September 2017

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Ikaros, CK2 kinase, and the road to leukemia

27 September 2017

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Improving outcomes for high-risk ALL: translating new discoveries into clinical care

27 September 2017

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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

27 September 2017

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Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.

27 September 2017

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Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

27 September 2017

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Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

27 September 2017

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Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation

27 September 2017

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Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.

27 September 2017

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Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms

27 September 2017

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Targeting CK2 for cancer therapy

27 September 2017

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Ikaros induces quiescence and T-cell differentiation in a leukemia cell line.

27 September 2017

1 reference

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Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition

27 September 2017

1 reference

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27 September 2017

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Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292658

Ikaros isoform x is selectively expressed in myeloid differentiation.

27 September 2017

1 reference

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A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains

27 September 2017

1 reference

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Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292658

Defects in hemopoietic stem cell activity in Ikaros mutant mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292658

Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292658

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292658

Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

27 September 2017

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Tumor suppression in T cell leukemia--the role of Ikaros

27 September 2017

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Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.

30 May 2018

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Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

30 May 2018

1 reference

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

21 January 2018

1 reference

New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice.

21 January 2018

1 reference

Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

21 January 2018

1 reference

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

1 reference

Genetic variation and the risk of acute lymphoblastic leukemia

21 January 2018

1 reference

Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia

21 January 2018

1 reference

12 December 2020

Homozygous deletions and point mutations of the Ikaros gene in gamma-ray-induced mouse thymic lymphomas

1 reference

12 December 2020

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1 reference

12 December 2020

Genetic inactivation of Ikaros is a rare event in human T-ALL

1 reference

12 December 2020

Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter

1 reference

12 December 2020