Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line (Q28188152)

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P Kaiser

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K A Won

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O Sangfelt

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S I Reed

Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

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publication date

20 September 2001

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language of work or name

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413

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issue

6853

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page(s)

316-22

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cites work

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Deregulated cyclin E induces chromosome instability

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

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Proteolysis and the cell cycle: with this RING I do thee destroy

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SCF and Cullin/Ring H2-based ubiquitin ligases

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How the cyclin became a cyclin: regulated proteolysis in the cell cycle

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

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The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E.

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E

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Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality

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Redundant cyclin overexpression and gene amplification in breast cancer cells

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

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Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28

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A rapid method for localized mutagenesis of yeast genes

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E

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Cyclin E in human cancers.

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