Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes (Q23912432)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=2836618

National Institute for Occupational Safety and Health

29 March 2017

sponsor

0 references

1 reference

19 July 2017

1 reference

29 March 2020

1 reference

29 March 2020

Vernon Wu

Vernon

Wu

5

2 references

19 October 2023

15 February 2024

Ehsan Sarafraz-Yazdi

1

1 reference

15 February 2024

Wilbur B Bowne

2

1 reference

15 February 2024

Victor Adler

3

1 reference

15 February 2024

Kelley A Sookraj

4

1 reference

15 February 2024

Vadim Shteyler

6

1 reference

15 February 2024

Hunaiz Patel

7

1 reference

15 February 2024

William Oxbury

8

1 reference

15 February 2024

Paul Brandt-Rauf

9

1 reference

15 February 2024

Michael E Zenilman

10

1 reference

15 February 2024

Josef Michl

11

1 reference

15 February 2024

Matthew R Pincus

12

1 reference

15 February 2024

language of work or name

English

0 references

publication date

11 January 2010

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=2836618

Proceedings of the National Academy of Sciences of the United States of America

29 March 2017

published in

1 reference

8 December 2019

107

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=2836618

29 March 2017

issue

5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=2836618

29 March 2017

page(s)

1918-1923

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pmc&retmode=json&id=2836618

29 March 2017

performing organization

Columbia University

object named as

Columbia University Health Sciences

1 reference

NIOSHTIC-2

on focus list of Wikimedia project

2 February 2024

Wikimedia–NIOSH collaboration

0 references

1 reference

25 September 2023

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Induction of a Common Pathway of Apoptosis by Staurosporine

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Identification of novel mdm2 binding peptides by phage display.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836618

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0909364107

Transducible peptide therapy for uveal melanoma and retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0909364107

Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0909364107

Kinetics of streptolysin O self-assembly

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20080680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20080680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Filling in the blanks in the p53 protein structure

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0909364107

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1073/PNAS.0909364107

1 reference