Defects in mucosal immunity leading to Crohn's disease (Q22242645)

Functional variants of OCTN cation transporter genes are associated with Crohn disease

Europe PubMed Central

title

Defects in mucosal immunity leading to Crohn's disease (English)

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Gena M. Cobrin

1

Gena M

Cobrin

1 reference

8 February 2023

Maria T. Abreu

series ordinal

2

author given names

Maria T

author last names

Abreu

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8 February 2023

language of work or name

English

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publication date

August 2005

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published in

Immunological Reviews

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volume

206

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issue

1

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page(s)

277-295

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cites work

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Responses to self and non-self intestinal microflora in health and inflammatory bowel disease

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Colonic bacteria express an ulcerative colitis pANCA-related protein epitope

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Pseudomonas fluorescens encodes the Crohn's disease-associated I2 sequence and T-cell superantigen

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Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival

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Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene

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Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Natural regulatory T cells in infectious disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Natural regulatory T cells and self-tolerance

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

CD4+ T regulatory cells from the colonic lamina propria of normal mice inhibit proliferation of enterobacteria-reactive, disease-inducing Th1-cells from scid mice with colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Comparative study of ASCA (Anti-Saccharomyces cerevisiae antibody) assays in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Transmembrane TNF-alpha, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Mucosal flora in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Distinct inflammatory mechanisms mediate early versus late colitis in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Crohn's disease is associated with a toll-like receptor-9 polymorphism

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Association of TNF-α-857C with Inflammatory Bowel Disease in the Australian Population

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Immunologic regulation of toll-like receptors in gut epithelium.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Update in inflammatory bowel disease pathogenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Innate immunity of the gut: mucosal defense in health and disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

THE EXTRA-INTESTINAL COMPLICATIONS OF CROHNʼS DISEASE AND ULCERATIVE COLITIS: A STUDY OF 700 PATIENTS

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Intestinal permeability and postheparin plasma diamine oxidase activity in the prediction of Crohn's disease relapse

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Inflammatory bowel disease-associated gene expression in intestinal epithelial cells by differential cDNA screening and mRNA display

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

A long-term cohort study of nonsteroidal anti-inflammatory drug use and disease activity in outpatients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Host-bacterial mutualism in the human intestine

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Immunity, inflammation, and allergy in the gut.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Smoking and Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

The granuloma in Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Intestinal permeability

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Cytokine gene polymorphisms in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

CARD4/NOD1 is not involved in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Chronic inflammatory bowel disease in children: a complex problem in management

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Investigation of the prognostic value of TNF-alpha gene polymorphism among patients treated with infliximab, and the effects of infliximab therapy on TNF-alpha production and apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Activation of a unique population of CD8(+) T cells by intestinal epithelial cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Failure to induce oral tolerance in Crohn's and ulcerative colitis patients: possible genetic risk

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021

Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00293.X

7 January 2021