Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface (Q22009461)

PubMed

PubMed publication ID

10219247

7 February 2023

W Sebald

series ordinal

2

author given names

W

author last names

Sebald

1 reference

PubMed

PubMed publication ID

10219247

7 February 2023

P Reinemer

series ordinal

3

author given names

P

author last names

Reinemer

1 reference

PubMed

PubMed publication ID

10219247

The interleukin-2 and interleukin-4 receptors studied by molecular modelling

7 February 2023

publication date

16 April 1999

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language of work or name

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97

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issue

2

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page(s)

271-81

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Structural design and molecular evolution of a cytokine receptor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Crystal structure of a cytokine-binding region of gp130.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

IL-4 and IL-13 receptors: are they one and the same?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

A hot spot of binding energy in a hormone-receptor interface

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Receptor binding properties of four-helix-bundle growth factors deduced from electrostatic analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Eosinophils in allergic reactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Sorting out the cytokines of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Requirement for IL-13 independently of IL-4 in experimental asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

A model of the complex between interleukin-4 and its receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

The interleukin‐4 site‐2 epitope determining binding of the common receptor γ chain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

The expanding universe of T-cell subsets: Th1, Th2 and more.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Lymphokine production by human T cells in disease states

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Structural comparisons among the short-chain helical cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Acquisition of lymphokine-producing phenotype by CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

An immune cell-selective interleukin 4 agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Human interleukin 4. The solution structure of a four-helix bundle protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Crystal structure of human recombinant interleukin-4 at 2.25 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980736-9

7 January 2021