hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways (Q22009420)

small GTPase mediated signal transduction

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

A Germani

1

A

Germani

1 reference

7 February 2023

F Romero

2

F

Romero

1 reference

7 February 2023

M Houlard

3

M

Houlard

1 reference

7 February 2023

J Camonis

4

J

Camonis

1 reference

7 February 2023

S Gisselbrecht

5

S

Gisselbrecht

1 reference

7 February 2023

S Fischer

6

S

Fischer

1 reference

7 February 2023

N Varin-Blank

7

N

Molecular and Cellular Biology

Varin-Blank

1 reference

7 February 2023

language of work or name

English

0 references

publication date

May 1999

0 references

published in

0 references

volume

19

0 references

page(s)

3798-807

0 references

issue

5

0 references

cites work

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

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Characterization of human homologs of the Drosophila seven in absentia (sina) gene

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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway

19 March 2017

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Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression

19 March 2017

1 reference

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Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

19 March 2017

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Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression

19 March 2017

1 reference

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p95vav associates with the nuclear protein Ku-70

19 March 2017

1 reference

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Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins

19 March 2017

1 reference

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Binding of Vav to Grb2 through dimerization of Src homology 3 domains

19 March 2017

1 reference

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Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

19 March 2017

1 reference

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Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

19 March 2017

1 reference

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DNA sequencing with chain-terminating inhibitors

19 March 2017

1 reference

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

19 March 2017

1 reference

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c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

19 March 2017

1 reference

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Transcription factors of the NFAT family: regulation and function

19 March 2017

1 reference

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Structure and function of vav

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

The RING finger domain: a recent example of a sequence-structure family

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Proteins regulating Ras and its relatives

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Sequence identification of 2,375 human brain genes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Lck regulates Vav activation of members of the Rho family of GTPases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

The proline-rich region of Vav binds to Grb2 and Grb3-3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Regulation of the yeast HO gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Proteasomal regulation of nuclear receptor corepressor-mediated repression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

SH2/SH3 signaling proteins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

A functional T-cell receptor signaling pathway is required for p95vav activity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Signal transduction in T lymphocytes using a conditional allele of Sos

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Mechanism of activation of the vav protooncogene

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Nuclear factors in sevenless signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

A new luciferase promoter insertion vector for the analysis of weak transcriptional activities

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Vav and Ras induce fibroblast transformation by overlapping signaling pathways which require c-Myc function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

MAP kinases: charting the regulatory pathways

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84217

Networking Rho family GTPases in lymphocytes

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10207103

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10207103