Jump to content

checkpoint kinase 2 (Q5011104)

From Wikidata
mammalian protein found in Homo sapiens
  • hCds1
  • CHEK2
  • CHK2 checkpoint homolog
  • checkpoint-like protein CHK2
  • Hucds1
  • serine/threonine-protein kinase Chk2
  • cds1 homolog
edit
Language Label Description Also known as
default for all languages
No label defined
    English
    checkpoint kinase 2
    mammalian protein found in Homo sapiens
    • hCds1
    • CHEK2
    • CHK2 checkpoint homolog
    • checkpoint-like protein CHK2
    • Hucds1
    • serine/threonine-protein kinase Chk2
    • cds1 homolog

    Statements

    molecular function
    protein serine/threonine kinase activity
    determination method or standard
    IDA
    TAS
    IEA
    6 references
    retrieved
    27 February 2018
    stated in
    Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    27 February 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    27 February 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    IEA
    retrieved
    27 February 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    IEA
    retrieved
    27 February 2018
    stated in
    Chk2 activates E2F-1 in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    IDA
    retrieved
    27 February 2018
    stated in
    Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    17 references
    retrieved
    8 April 2019
    stated in
    Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Per3, a circadian gene, is required for Chk2 activation in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Systematic identification of molecular links between core and candidate genes in breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IPI
    protein serine/threonine kinase activity
    determination method or standard
    IBA
    IDA
    IEA
    TAS
    7 references
    retrieved
    8 April 2019
    stated in
    Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Chk2 activates E2F-1 in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IBA
    cell component
    biological process
    cellular response to DNA damage stimulus
    determination method or standard
    IDA
    TAS
    IMP
    IEA
    5 references
    retrieved
    8 April 2019
    stated in
    Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    O96017
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
    determination method or standard
    IDA
    Gene Atlas image
    PBB GE CHEK2 210416 s at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D064447
    subject named as
    Checkpoint Kinase 2
    0 references
    RefSeq protein ID
    Ensembl protein ID
    PDB structure ID
     
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    edit
                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q5011104&oldid=2383228138"