Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15) (Q21710694)

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20 February 2020

review article

1 reference

title

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

part of the series

Gene Wiki Review Series

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1

Igor Ivanov

Igor

Ivanov

1 reference

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20 February 2020

2

Hartmut Kuhn

Hartmut

Kuhn

1 reference

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20 February 2020

3

Dagmar Heydeck

Dagmar

Heydeck

1 reference

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20 February 2020

language of work or name

English

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publication date

26 July 2015

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20 February 2020

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20 February 2020

volume

573

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20 February 2020

page(s)

1-32

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20 February 2020

issue

1

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Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

20 February 2020

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12 December 2020

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

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12 December 2020

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

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12 December 2020

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

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12 December 2020

Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects

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12 December 2020

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

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12 December 2020

Thrombin-induced growth cone collapse: involvement of phospholipase A(2) and eicosanoid generation

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12 December 2020

Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.

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12 December 2020

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

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12 December 2020

Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription

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12 December 2020

The N-terminal beta-barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies

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12 December 2020

Thrombin causes pseudopod detachment via a pathway involving cytosolic phospholipase A2 and 12/15-lipoxygenase products

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12 December 2020

Rat testis lipoxygenase-like enzyme characterization of products from linoleic acid

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12 December 2020

Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin

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12 December 2020

Ligand binding and conformational motions in myoglobin

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12 December 2020

Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes

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12 December 2020

The oxidative modification hypothesis of atherogenesis: an overview

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12 December 2020

Discovery of an 11 (R)- and 12(S)-lipoxygenase activity in ovaries of the mussel Mytilus edulis

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12 December 2020

The Lipoxygenase of Reticulocytes. Purification, Characterization and Biological Dynamics of the Lipoxygenase; Its Identity with the Respiratory Inhibitors of the Reticulocyte

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12 December 2020

Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells

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12 December 2020

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

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12 December 2020

Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte

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12 December 2020

Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice

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12 December 2020

Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells

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12 December 2020

Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions.

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12 December 2020

Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity

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12 December 2020

Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.

1 reference

12 December 2020

Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene

1 reference

12 December 2020

Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis

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12 December 2020

12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice

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12 December 2020

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

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12 December 2020

Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3'-UTR control element DICE.

1 reference

12 December 2020

The action of lipoxygenase-1 on furan derivatives

1 reference

12 December 2020

The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding

1 reference

12 December 2020

15-lipoxygenase-1: a prooxidant enzyme

1 reference

12 December 2020

Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase

1 reference

12 December 2020

The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides

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12 December 2020

GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma

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12 December 2020

Lipoxygenase genes and their targeted disruption

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12 December 2020

Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition

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12 December 2020

Suicidal inactivation of the rabbit 15-lipoxygenase by 15S-HpETE is paralleled by covalent modification of active site peptides

1 reference

12 December 2020

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

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12 December 2020

Density-functional investigation on the mechanism of H-atom abstraction by lipoxygenase

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12 December 2020

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

1 reference

12 December 2020

Gene profiling in spinal cord injury shows role of cell cycle in neuronal death

1 reference

12 December 2020

Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase

1 reference

12 December 2020

Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase

1 reference

12 December 2020

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

1 reference

12 December 2020

Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.

1 reference

12 December 2020

Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma

1 reference

12 December 2020

Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

1 reference

12 December 2020

Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta

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12 December 2020

The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways

1 reference

12 December 2020

Kinetic Studies of Oxygen Reactivity in Soybean Lipoxygenase-1

1 reference

12 December 2020

Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium

1 reference

12 December 2020

12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses.

1 reference

12 December 2020

Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes

1 reference

12 December 2020

Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance

1 reference

12 December 2020

Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets.

1 reference

12 December 2020

Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide

1 reference

12 December 2020

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

1 reference

12 December 2020

15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells

1 reference

12 December 2020

Characterization of calcium and magnesium binding domains of human 5-lipoxygenase

1 reference

12 December 2020

Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase

1 reference

12 December 2020

Cloning and expression of an airway epithelial 12-lipoxygenase

1 reference

12 December 2020

12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes

1 reference

12 December 2020

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice

1 reference

12 December 2020

Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding

1 reference

12 December 2020

Localization of arachidonate 12-lipoxygenase in canine brain tissues

1 reference

12 December 2020

A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation

1 reference

12 December 2020

Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation

1 reference

12 December 2020

Enantioselective substrate specificity of 15-lipoxygenase 1.

1 reference

12 December 2020

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity

1 reference

12 December 2020

Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13.

1 reference

12 December 2020

Structural stability of soybean lipoxygenase-1 in solution as probed by small angle X-ray scattering

1 reference

12 December 2020

Dual role of oxygen during lipoxygenase reactions

1 reference

12 December 2020

Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment

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12 December 2020

15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet

1 reference

12 December 2020

A comprehensive model of positional and stereo control in lipoxygenases

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12 December 2020

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

1 reference

12 December 2020

Inhibition of carcinogenesis in transgenic mouse models over-expressing 15-lipoxygenase in the vascular wall under the control of murine preproendothelin-1 promoter.

1 reference

12 December 2020

On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant

1 reference

12 December 2020

Neuroprotective properties of the natural vitamin E alpha-tocotrienol

1 reference

12 December 2020

Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.

1 reference

12 December 2020

Identification of 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid as a novel and potent human eosinophil chemotactic eicosanoid

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12 December 2020

The role of lipoxygenase-isoforms in atherogenesis

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12 December 2020

12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway

1 reference

12 December 2020

Structure of the leucine zipper

1 reference

12 December 2020

Lipoxin biosynthesis in inflammatory bowel disease

1 reference

12 December 2020

Affinity labeling of the rabbit 12/15-lipoxygenase using azido derivatives of arachidonic acid

1 reference

12 December 2020

In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions

1 reference

12 December 2020

15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophages

1 reference

12 December 2020

Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.

1 reference

12 December 2020

Inflammation and immune regulation by 12/15-lipoxygenases

1 reference

12 December 2020

Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin

1 reference

12 December 2020

The DICE-binding Activity of KH Domain 3 of hnRNP K Is Affected by c-Src-mediated Tyrosine Phosphorylation

1 reference

12 December 2020

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions

1 reference

12 December 2020

Baicalein and 12/15-lipoxygenase in the ischemic brain.

1 reference

12 December 2020

Arachidonate 15-lipoxygenase and ubiquitin as fertility markers in boars

1 reference

12 December 2020

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase

1 reference

12 December 2020

The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria

1 reference

12 December 2020

Synthesis of phenyl-substituted amides with antioxidant and anti-inflammatory activity as novel lipoxygenase inhibitors

1 reference

12 December 2020

Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease

1 reference

12 December 2020

12R-lipoxygenase deficiency disrupts epidermal barrier function

1 reference

12 December 2020

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

1 reference

12 December 2020

Role of oxidized low density lipoprotein in atherogenesis

1 reference

12 December 2020

Diabetic cardiomyopathy revisited

1 reference

12 December 2020

13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells

1 reference

12 December 2020

Structure, biochemistry and biology of hepoxilins: an update

1 reference

12 December 2020

Reticulocyte-secreted exosomes bind natural IgM antibodies: involvement of a ROS-activatable endosomal phospholipase iPLA2.

1 reference

12 December 2020

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

1 reference

12 December 2020

Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

1 reference

12 December 2020

The two faces of the 15-lipoxygenase in atherosclerosis

1 reference

12 December 2020

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.

1 reference

12 December 2020

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes

1 reference

12 December 2020

Lipoxygenase metabolism: roles in tumor progression and survival

1 reference

12 December 2020

Novel lipoxygenase inhibitors as neuroprotective reagents

1 reference

12 December 2020

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution

1 reference

12 December 2020

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

1 reference

12 December 2020

15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation

1 reference

12 December 2020

Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells

1 reference

12 December 2020

Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems

1 reference

12 December 2020

Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process

2 references

12 December 2020

Crossref

https://api.crossref.org/works/10.1016%2FJ.GENE.2015.07.073

7 January 2021

inferred from DOI database lookup

mRNA silencing in human erythroid cell maturation: heterogeneous nuclear ribonucleoprotein K controls the expression of its regulator c-Src

1 reference

12 December 2020

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

1 reference

12 December 2020

12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.

1 reference

12 December 2020

Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia

1 reference

12 December 2020

The 15-lipoxygenase-modified high density lipoproteins 3 fail to inhibit the TNF-alpha-induced inflammatory response in human endothelial cells

1 reference

12 December 2020

Structural properties of plant and mammalian lipoxygenases. Temperature-dependent conformational alterations and membrane binding ability.

1 reference

12 December 2020

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet

1 reference

12 December 2020

Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension

1 reference

12 December 2020

The oxygenation of cholesterol esters by the reticulocyte lipoxygenase

1 reference

12 December 2020

On the mechanistic reasons for the dual positional specificity of the reticulocyte lipoxygenase

1 reference

12 December 2020

The LDL modification hypothesis of atherogenesis: an update

1 reference

12 December 2020

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

1 reference

12 December 2020

Metabolism of arachidonic acid in nervous system of marine mollusk Aplysia californica

1 reference

12 December 2020

Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries

1 reference

12 December 2020

On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

1 reference

12 December 2020

Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols

1 reference

12 December 2020

15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.

1 reference

12 December 2020

Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.

1 reference

12 December 2020

Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport

1 reference

12 December 2020

The hepoxilins and some analogues: a review of their biology

1 reference

12 December 2020

Anticancer actions of omega-3 fatty acids--current state and future perspectives

1 reference

12 December 2020

A primary determinant for lipoxygenase positional specificity

1 reference

12 December 2020

Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice

1 reference

12 December 2020

Lipoxin a(4) attenuates microvascular fluid leak during inflammation

1 reference

12 December 2020

Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone

1 reference

12 December 2020

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis

1 reference

12 December 2020

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

1 reference

12 December 2020

15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29.

1 reference

12 December 2020

12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice

1 reference

12 December 2020

The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation

1 reference

12 December 2020

Resolvin E1 receptor activation signals phosphorylation and phagocytosis

1 reference

12 December 2020

Applicability of the triad concept for the positional specificity of mammalian lipoxygenases

1 reference

12 December 2020

Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.

1 reference

12 December 2020

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets

1 reference

12 December 2020

Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells

1 reference

12 December 2020

Cloning, purification and characterization of non-human primate 12/15-lipoxygenases.

1 reference

12 December 2020

12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels

1 reference

12 December 2020

9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes

1 reference

12 December 2020

Degradation of mitochondria by cytosolic factors in reticulocytes

1 reference

12 December 2020

Autophagy: cellular and molecular mechanisms

1 reference

12 December 2020

Lipoxins: regulators of resolution

1 reference

12 December 2020

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity

1 reference

12 December 2020

Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice

1 reference

12 December 2020

Insights into the mechanism of binding of arachidonic acid to mammalian 15-lipoxygenases.

1 reference

12 December 2020

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins

1 reference

12 December 2020

Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice

1 reference

12 December 2020

Lipoxin and aspirin-triggered lipoxins.

1 reference

12 December 2020

Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity

1 reference

12 December 2020

Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase

1 reference

12 December 2020

Transcellular biosynthesis of eicosanoids

1 reference

12 December 2020

Molecular enzymology of lipoxygenases

1 reference

12 December 2020

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

1 reference

12 December 2020

DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules

1 reference

12 December 2020

Eoxins: a new inflammatory pathway in childhood asthma

1 reference

12 December 2020

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids

1 reference

12 December 2020

On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.

1 reference

12 December 2020

Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease

1 reference

12 December 2020

Functional and pathological roles of the 12- and 15-lipoxygenases

1 reference

12 December 2020

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

1 reference

12 December 2020

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats

1 reference

12 December 2020

Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells

1 reference

12 December 2020

Structure of human pancreatic lipase

1 reference

12 December 2020

Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4.

1 reference

12 December 2020

Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation.

1 reference

12 December 2020

Role of lipoxygenase in the mechanism of acrosome reaction in mammalian spermatozoa

1 reference

12 December 2020

Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects

1 reference

12 December 2020

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice

1 reference

12 December 2020

Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes

1 reference

12 December 2020

On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme

1 reference

12 December 2020

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

1 reference

12 December 2020

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms

1 reference

12 December 2020

Molecular dynamics simulation of mammalian 15S-lipoxygenase with AMBER force field

1 reference

12 December 2020

Hepoxilin A3 protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid

1 reference

12 December 2020

Docosahexaenoic Acid therapy of experimental ischemic stroke

1 reference

12 December 2020

Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone

1 reference

12 December 2020

Probing Dimerization and Structural Flexibility of Mammalian Lipoxygenases by Small-Angle X-ray Scattering

1 reference

12 December 2020

15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma

1 reference

12 December 2020

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase

1 reference

12 December 2020

Resolvins and protectins in inflammation resolution.

1 reference

12 December 2020

Ultrastructural features of human atherosclerosis

1 reference

12 December 2020

Substrate binding to mammalian 15-lipoxygenase

1 reference

12 December 2020

Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept

1 reference

12 December 2020

Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

1 reference

12 December 2020

The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions

1 reference

12 December 2020

The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis

1 reference

12 December 2020

Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer

1 reference

12 December 2020

Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.

1 reference

12 December 2020

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

1 reference

12 December 2020

Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?

1 reference

12 December 2020

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

1 reference

12 December 2020

Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension.

1 reference

12 December 2020

Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension

1 reference

12 December 2020

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

1 reference

12 December 2020

Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes

1 reference

12 December 2020

The ins and outs of human reticulocyte maturation: autophagy and the endosome/exosome pathway

1 reference

12 December 2020

Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation

1 reference

12 December 2020

Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer's disease brain

1 reference

12 December 2020

Inflammation in atherosclerosis

1 reference

12 December 2020

Redox control of cell proliferation

1 reference

12 December 2020

12- and 15-lipoxygenases in adipose tissue inflammation

1 reference

12 December 2020

Overproduction, purification, and characterization of extracellular lipoxygenase of Pseudomonas aeruginosa in Escherichia coli.

1 reference

12 December 2020

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling

1 reference

12 December 2020

Upregulation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human endothelial cells by modified high density lipoproteins

1 reference

12 December 2020

Sterols in spermatogenesis and sperm maturation.

1 reference

12 December 2020

12S-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients

1 reference

12 December 2020

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

1 reference

12 December 2020

Cellular redox, epigenetics and diseases

1 reference

12 December 2020

Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes

1 reference

12 December 2020

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

1 reference

12 December 2020

Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines

1 reference

12 December 2020

Redox control of inflammation in macrophages

1 reference

12 December 2020

Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet

1 reference

12 December 2020

Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders

1 reference

12 December 2020

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia

1 reference

12 December 2020

Lipoxygenase: an emerging target for stroke therapy

1 reference

12 December 2020

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development

1 reference

12 December 2020

12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase

1 reference

12 December 2020

Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase

1 reference

12 December 2020

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms

1 reference

12 December 2020

The role of redox signaling in epigenetics and cardiovascular disease

1 reference

12 December 2020

An insight into the regiospecificity of linoleic acid peroxidation catalyzed by mammalian 15-lipoxygenases.

1 reference

12 December 2020

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

1 reference

12 December 2020

Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

1 reference

12 December 2020

12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction

1 reference

12 December 2020

5-Lipoxygenase inhibitors: a review of recent patents (2010-2012).

1 reference

12 December 2020

Bacterial lipoxygenases, a new subfamily of enzymes? A phylogenetic approach.

1 reference

12 December 2020

Novel n-3 immunoresolvents: structures and actions

1 reference

12 December 2020

12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia

1 reference

12 December 2020

The erythroid arachidonate 15-lipoxygenase in rat reticulocytes

1 reference

12 December 2020

Natural resolution of inflammation

1 reference

12 December 2020

15-Lipoxygenases in cancer: a double-edged sword?

1 reference

12 December 2020

Autophagy and Mitophagy in Cellular Damage Control

1 reference

12 December 2020

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa

1 reference

12 December 2020

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

1 reference

12 December 2020

15(S)-HETE-induced angiogenesis in adipose tissue is mediated through activation of PI3K/Akt/mTOR signaling pathway

1 reference

12 December 2020

Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke

1 reference

12 December 2020

Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases

1 reference

12 December 2020

Functional characterization of genetic enzyme variations in human lipoxygenases

1 reference

12 December 2020

Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells

1 reference

12 December 2020

Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.

1 reference

12 December 2020

Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis

1 reference

12 December 2020

Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives

1 reference

12 December 2020

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1 reference

12 December 2020

Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells

1 reference

12 December 2020

15-lipoxygenase inhibition, superoxide and hydroxyl radicals scavenging activities of Cedrus brevifolia bark extracts

1 reference

12 December 2020

15-Lipoxygenase-Mediated Modification of HDL3 Impairs eNOS Activation in Human Endothelial Cells

1 reference

12 December 2020

Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer

1 reference

12 December 2020

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

1 reference

12 December 2020

Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation

1 reference

12 December 2020

Regio- and Stereospecificity in the Oxygenation of Arachidonic Acid Catalyzed by Leu597 Mutants of Rabbit 15-Lipoxygenase: A QM/MM Study

1 reference

12 December 2020

PPARγ and the global map of adipogenesis and beyond

1 reference

12 December 2020

The role of inflammation in colon cancer

1 reference

12 December 2020

Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases

1 reference

12 December 2020

Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes

1 reference

12 December 2020

Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis.

1 reference

12 December 2020

Biophysical and biochemical analysis of hnRNP K: arginine methylation, reversible aggregation and combinatorial binding to nucleic acids.

1 reference

12 December 2020

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3).

1 reference

12 December 2020

Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes

1 reference

12 December 2020

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase

1 reference

12 December 2020

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

1 reference

12 December 2020

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

1 reference

12 December 2020

Introducing Mutations to Modify the C13/C9 Ratio in Linoleic Acid Oxygenations Catalyzed by Rabbit 15-Lipoxygenase: A QM/MM and MD Study

1 reference

12 December 2020

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.

1 reference

12 December 2020

Pathophysiology of the hepoxilins

1 reference

12 December 2020

A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology

1 reference

12 December 2020

Activation of PPARγ by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury

1 reference

12 December 2020

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

1 reference

12 December 2020

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens

1 reference

12 December 2020

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

1 reference

12 December 2020

A novel role for 12/15-lipoxygenase in regulating autophagy

1 reference

12 December 2020

The structural basis for specificity in lipoxygenase catalysis

1 reference

12 December 2020

12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

1 reference

12 December 2020

The role of leukotrienes in allergic diseases

1 reference

12 December 2020

Insulin resistance and impaired adipogenesis

1 reference

12 December 2020

Antioxidant and anti-lipoxygenase activities of extracts from different parts of Lavatera cretica L. grown in Algarve (Portugal).

1 reference

12 December 2020

Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation

1 reference

12 December 2020

Lipoxygenase-like enzyme in bat testis microsomes

1 reference

12 December 2020

Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes

1 reference

12 December 2020

Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase

1 reference

12 December 2020

The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases

1 reference

12 December 2020

Molecular cloning and amino acid sequence of human 5-lipoxygenase

1 reference

12 December 2020

Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4

1 reference

12 December 2020

The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity

1 reference

12 December 2020

Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes

1 reference

12 December 2020

Enzymology and physiology of reticulocyte lipoxygenase: comparison with other lipoxygenases

1 reference

12 December 2020

The stereochemistry of the reactions of lipoxygenases and their metabolites. Proposed nomenclature of lipoxygenases and related enzymes

1 reference

12 December 2020

Requirement of monohydroperoxy fatty acids for the oxygenation of 15LS-HETE by reticulocyte lipoxygenase

1 reference

12 December 2020

Role of arachidonate metabolism on the in vitro release of luteinizing hormone and prolactin from the anterior pituitary gland: possible involvement of lipoxygenase pathway.

1 reference

12 December 2020

The maturational breakdown of mitochondria in reticulocytes

1 reference

12 December 2020

Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity

1 reference

12 December 2020

Arachidonic acid metabolism in a cloned strain of rat pituitary tumor cells: correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process

1 reference

12 December 2020

Vascular lipoxygenase activity: synthesis of 15-hydroxyeicosatetraenoic acid from arachidonic acid by blood vessels and cultured vascular endothelial cells

1 reference

12 December 2020

Arachidonic acid and its lipoxygenase metabolites stimulate prolactin release in superfused pituitary cells

1 reference

12 December 2020

A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes

1 reference

12 December 2020

Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids

1 reference

12 December 2020

Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation

1 reference

12 December 2020

Cloning of a rabbit erythroid-cell-specific lipoxygenase mRNA.

1 reference

12 December 2020

15-Lipoxygenase products stimulate prolactin secretion from a cloned strain of rat pituitary cells

1 reference

12 December 2020

The biological dynamics of lipoxygenase in rabbit red cells in the course of an experimental bleeding anaemia. Unexpected effects of the calcium ionophore A 23187.

1 reference

12 December 2020

Evidence for the involvement of lipoxygenase products in steroidogenesis

1 reference

12 December 2020

On the nature of the stimulation of the lipoxygenase from rabbit reticulocytes by biological membranes

1 reference

12 December 2020

Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets

1 reference

12 December 2020

The detection of linoleic acid radicals in the anaerobic reaction of lipoxygenase

1 reference

12 December 2020

The origin and structures of dimeric fatty acids from the anaerobic reaction between soya-bean lipoxygenase, linoleic acid and its hydroperoxide

1 reference

12 December 2020

An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides

1 reference

12 December 2020

Autophagic vacuoles in human red cells

1 reference

12 December 2020

Maturation of the reticulocyte in vitro

1 reference

12 December 2020

Control of Steroidogenesis in Leydig Cells: Roles of Ca2+and Lipoxygenase Products in LH and LHRH Agonist Action

1 reference

12 December 2020

Purification and properties of arachidonate-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes

1 reference

12 December 2020

The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin

1 reference

12 December 2020

Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes

1 reference

12 December 2020

Induction of brain edema following intracerebral injection of arachidonic acid

1 reference

12 December 2020

A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria

1 reference

12 December 2020

Penetration of dioxygen into proteins studied by quenching of phosphorescence and fluorescence

1 reference

12 December 2020

Methionine sulfoxide formation: the cause of self-inactivation of reticulocyte lipoxygenase

1 reference

12 December 2020

In vitro maturation of rabbit reticulocytes. III. Response of lipoxygenase

1 reference

12 December 2020

Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen

1 reference

12 December 2020

Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis

1 reference

12 December 2020

Pentane formation during the anaerobic reactions of reticulocyte lipoxygenase. Comparison with lipoxygenases from soybeans and green pea seeds

1 reference

12 December 2020

Brain edema: induction in cortical slices by polyunsaturated fatty acids.

1 reference

12 December 2020

Double dioxygenation of arachidonic acid by soybean lipoxygenase-1. Kinetics and regio-stereo specificities of the reaction steps

1 reference

12 December 2020

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid

1 reference

12 December 2020

Self-inactivation by 13-hydroperoxylinoleic acid and lipohydroperoxidase activity of the reticulocyte lipoxygenase

1 reference

12 December 2020

Lipoxygenase mRNA in rabbit reticulocytes. Its isolation, characterization and translational repression

1 reference

12 December 2020

Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.

1 reference

12 December 2020

Lipoxygenase-mediated glutathione oxidation and superoxide generation

1 reference

12 December 2020

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques

1 reference

12 December 2020

Identification of a specific methionine in mammalian 15-lipoxygenase which is oxygenated by the enzyme product 13-HPODE: dissociation of sulfoxide formation from self-inactivation

1 reference

12 December 2020

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes

1 reference

12 December 2020

Inhibition by superoxide dismutase of linoleic acid peroxidation induced by lipoxidase

1 reference

12 December 2020

Conversion of linoleic acid hydroperoxide by soybean lipoxygenase in the presence of guaiacol: identification of the reaction products

1 reference

12 December 2020

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region

1 reference

12 December 2020

The Dioxygenation Rate In Lipoxygenase Catalysis Is Determined by the Amount of Iron(III) Lipoxygenase in Solution

1 reference

12 December 2020

Involvement of 15-lipoxygenase in early stages of atherogenesis

1 reference

12 December 2020

Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases

1 reference

12 December 2020

Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase.

1 reference

12 December 2020

Overexpression, purification and characterization of human recombinant 15-lipoxygenase

1 reference

12 December 2020

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins

1 reference

12 December 2020

Molecular cloning of a 12-lipoxygenase cDNA from rat brain

1 reference

12 December 2020

Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid

1 reference

12 December 2020

Oxygenation of lipoproteins by mammalian lipoxygenases.

1 reference

12 December 2020

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells

1 reference

12 December 2020

Rat 12-lipoxygenase: mutations of amino acids implicated in the positional specificity of 15- and 12-lipoxygenases

1 reference

12 December 2020

Arachidonate 12-lipoxygenase in porcine anterior pituitary cells: its localization and possible function in gonadotrophs

1 reference

12 December 2020

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products

1 reference

12 December 2020

Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases.

1 reference

12 December 2020

Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

1 reference

12 December 2020

Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.

1 reference

12 December 2020

Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein

1 reference

12 December 2020

Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis

1 reference

12 December 2020

Involvement of the 12-lipoxygenase pathway of arachidonic acid metabolism in homosynaptic long-term depression of the rat hippocampus.

1 reference

12 December 2020

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

1 reference

12 December 2020

Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases.

1 reference

12 December 2020

Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids

1 reference

12 December 2020

In vivo action of 15-lipoxygenase in early stages of human atherogenesis

1 reference

12 December 2020

Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid

1 reference

12 December 2020

Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties

1 reference

12 December 2020

mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.

1 reference

12 December 2020

Discovery of a second 15S-lipoxygenase in humans

1 reference

12 December 2020

Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat Leydig cells

1 reference

12 December 2020

Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima.

1 reference

12 December 2020

Ligand migration in sperm whale myoglobin.

1 reference

12 December 2020

Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl Esters

1 reference

12 December 2020

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

1 reference

12 December 2020

Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme

1 reference

12 December 2020

Arthur C. Corcoran Memorial Lecture. The role of eicosanoids in angiotensin-dependent hypertension

1 reference

12 December 2020

Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiation

1 reference

12 December 2020

A role for lipoxygenase metabolites of arachidonic acid in porcine ovulation

1 reference

12 December 2020

The iron ligand sphere geometry of mammalian 15-lipoxygenases

1 reference

12 December 2020

Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits

1 reference

12 December 2020

Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes

2 references

12 December 2020

Crossref

https://api.crossref.org/works/10.1016%2FJ.GENE.2015.07.073

7 January 2021

inferred from DOI database lookup

The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E.

1 reference

12 December 2020

Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6

1 reference

12 December 2020

A function for lipoxygenase in programmed organelle degradation

1 reference

12 December 2020

Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation.

1 reference

12 December 2020

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta

1 reference

12 December 2020

Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site

1 reference

12 December 2020

Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes

1 reference

12 December 2020

The role of 12-lipoxygenase in pancreatic -cells (Review).

1 reference

12 December 2020

Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.

1 reference

12 December 2020

Mammalian lipoxygenases and their biological relevance

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.GENE.2015.07.073

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.GENE.2015.07.073

2 references

Consolidated OpenCitations Corpus – April 2017

2589787

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

2589787

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

2 references

Consolidated OpenCitations Corpus – April 2017

2589787

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216303%20AND%20SRC:MED&resulttype=core&format=json