Eukaryotic translation initiation factor 4A1 (Q21173749)

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mammalian protein found in Homo sapiens

eukaryotic translation initiation factor 4A
EIF4A1
eukaryotic initiation factor 4A-I
ATP-dependent RNA helicase eIF4A-1
eukaryotic initiation factor 4AI

Language	Label	Description	Also known as
English	Eukaryotic translation initiation factor 4A1	mammalian protein found in Homo sapiens	eukaryotic translation initiation factor 4A EIF4A1 eukaryotic initiation factor 4A-I ATP-dependent RNA helicase eIF4A-1 eukaryotic initiation factor 4AI

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEAD/DEAH box helicase

1 reference

based on heuristic

inferred from protein domain or family

RNA helicase, DEAD-box type, Q motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

ATP-dependent RNA helicase DEAD-box, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

translation factor activity, RNA binding

determination method

protein binding

determination method

13 references

8 April 2019

Cell stress modulates the function of splicing regulatory protein RBM4 in translation control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

An oxygen-regulated switch in the protein synthesis machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Structural basis for the enhancement of eIF4A helicase activity by eIF4G.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Crystal structure of the eIF4A-PDCD4 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Translational repression precedes and is required for ZAP-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Cell stress modulates the function of splicing regulatory protein RBM4 in translation control

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

RNA cap binding

determination method

1 reference

8 April 2019

Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

double-stranded RNA binding

determination method

1 reference

8 April 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

determination method

3 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

determination method

1 reference

8 April 2019

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

eukaryotic translation initiation factor 4F complex

determination method

1 reference

8 April 2019

Characterization of the cloned promoter of the human initiation factor 4AI gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

extracellular exosome

determination method

determination method

1 reference

8 April 2019

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

extracellular matrix

determination method

1 reference

17 October 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

biological process

nuclear-transcribed mRNA poly(A) tail shortening

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

RNA secondary structure unwinding

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

translational initiation

determination method

regulation of gene expression

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60842&geneProductId=UniProtKB:P60842

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

protein biosynthesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60842

determination method

RNA helicase, DEAD-box type, Q motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

ATP-dependent RNA helicase DEAD-box, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

DEAD/DEAH box helicase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

Helicase superfamily 1/2, ATP-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

Helicase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60842

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000293831

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000293831

ENSP00000463486

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463486

ENSP00000461921

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461921

ENSP00000462275

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462275

ENSP00000462372

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462372

ENSP00000462581

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462581

ENSP00000462719

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462719

ENSP00000462741

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462741

ENSP00000462753

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462753

ENSP00000462904

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462904

ENSP00000463067

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463067

ENSP00000463309

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463309

ENSP00000463366

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463366

ENSP00000463380

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463380

ENSP00000463634

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463634

ENSP00000463821

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463821

ENSP00000464066

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464066

ENSP00000464082

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464082

ENSP00000464320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464320

ENSP00000464550

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464550

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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