Rho guanine nucleotide exchange factor 1 (Q21170262)

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mammalian protein found in Homo sapiens

Sub1.5
p115-RhoGEF
115 kDa guanine nucleotide exchange factor
rho guanine nucleotide exchange factor 1
115-kD protein
Rho guanine nucleotide exchange factor (GEF) 1
p115RhoGEF
Lsc homolog
ARHGEF1

Language	Label	Description	Also known as
English	Rho guanine nucleotide exchange factor 1	mammalian protein found in Homo sapiens	Sub1.5 p115-RhoGEF 115 kDa guanine nucleotide exchange factor rho guanine nucleotide exchange factor 1 115-kD protein Rho guanine nucleotide exchange factor (GEF) 1 p115RhoGEF Lsc homolog ARHGEF1

Statements

1 reference

13 November 2019

UniProt protein ID

Dbl homology (DH) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92888

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92888

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92888

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

p115RhoGEF, RGS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dbl homology (DH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

8 April 2019

Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

8 April 2019

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

determination method

1 reference

31 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92888&geneProductId=UniProtKB:Q92888

determination method

guanyl-nucleotide exchange factor activity

determination method

G protein-coupled receptor binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

determination method

3 references

8 April 2019

Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

biological process

cell population proliferation

determination method

1 reference

1 January 2018

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

Rho protein signal transduction

determination method

1 reference

8 April 2019

Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

regulation of small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92888

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92888&geneProductId=UniProtKB:Q92888

determination method

regulation of molecular function

determination method

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92888&geneProductId=UniProtKB:Q92888

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000337261

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337261

ENSP00000344429

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344429

ENSP00000346532

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346532

ENSP00000367394

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367394

ENSP00000469409

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469409

ENSP00000469735

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469735

ENSP00000470042

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470042

ENSP00000470557

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470557

ENSP00000470715

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470715

ENSP00000471942

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471942

ENSP00000472466

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472466

ENSP00000473229

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473229

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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