Serine and arginine rich splicing factor 2 (Q21156241)

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mammalian protein found in Homo sapiens
  • SR splicing factor 2
  • splicing factor, arginine/serine-rich 2
  • serine/arginine-rich splicing factor 2
  • Protein PR264
  • SC-35
  • SRSF2
  • splicing component, 35 kDa
  • splicing factor SC35
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Language Label Description Also known as
English
Serine and arginine rich splicing factor 2
mammalian protein found in Homo sapiens
  • SR splicing factor 2
  • splicing factor, arginine/serine-rich 2
  • serine/arginine-rich splicing factor 2
  • Protein PR264
  • SC-35
  • SRSF2
  • splicing component, 35 kDa
  • splicing factor SC35

Statements

molecular function
protein binding
determination method
IPI
8 references
retrieved
9 May 2019
stated in
A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
SON controls cell-cycle progression by coordinated regulation of RNA splicing
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
retrieved
9 May 2019
stated in
Spatial mapping of splicing factor complexes involved in exon and intron definition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IPI
cell component
nuclear speck
determination method
IDA
IEA
7 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
26 September 2017
stated in
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
26 September 2017
stated in
The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
26 September 2017
stated in
Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
26 September 2017
stated in
A novel SR-related protein is required for the second step of Pre-mRNA splicing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
26 September 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
nucleus
determination method
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
1 January 2018
stated in
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
1 January 2018
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
1 January 2018
stated in
HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
1 January 2018
stated in
The human DEK oncogene regulates DNA damage response signaling and repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
1 January 2018
stated in
Characterization of cyclin L1 as an immobile component of the splicing factor compartment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
1 January 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01130&geneProductId=UniProtKB:Q01130
determination method
IDA
nuclear speck
determination method
IBA
IDA
IEA
TAS
9 references
retrieved
9 May 2019
stated in
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
9 May 2019
stated in
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
A novel SR-related protein is required for the second step of Pre-mRNA splicing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IBA
nucleus
determination method
IBA
IDA
IEA
9 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IEA
retrieved
9 May 2019
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.
GOA
curator
UniProt
UniProt protein ID
Q01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
The human DEK oncogene regulates DNA damage response signaling and repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
Characterization of cyclin L1 as an immobile component of the splicing factor compartment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01130
determination method
IBA
biological process

Identifiers

 
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