transcription factor A, mitochondrial (Q21154403)

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mammalian protein found in Homo sapiens

Transcription factor 6-like 2
transcription factor 6-like 1
transcription factor 6
transcription factor 6-like 3
MtTF1
TCF-6
mitochondrial transcription factor A
mitochondrial transcription factor 1
TFAM
transcription factor 6-like 2 (mitochondrial transcription factor)

Language	Label	Description	Also known as
English	transcription factor A, mitochondrial	mammalian protein found in Homo sapiens	Transcription factor 6-like 2 transcription factor 6-like 1 transcription factor 6 transcription factor 6-like 3 MtTF1 TCF-6 mitochondrial transcription factor A mitochondrial transcription factor 1 TFAM transcription factor 6-like 2 (mitochondrial transcription factor)

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

High mobility group box domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00059

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

mitochondrial promoter sequence-specific DNA binding

determination method

1 reference

26 September 2017

Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

heat shock protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

26 September 2017

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

chromatin binding

determination method

1 reference

8 April 2019

The layered structure of human mitochondrial DNA nucleoids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

26 September 2017

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

protein binding

determination method

4 references

8 April 2019

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

8 April 2019

Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

transcription coactivator binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

DNA binding, bending

determination method

1 reference

8 April 2019

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

sequence-specific DNA binding

determination method

1 reference

8 April 2019

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

mitochondrial matrix

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

determination method

4 references

26 September 2017

Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

mitochondrial nucleoid

determination method

determination method

1 reference

26 September 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

determination method

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

biological process

DNA-dependent DNA replication

determination method

1 reference

26 September 2017

Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

regulation of transcription, DNA-templated

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

regulation of transcription by RNA polymerase I

determination method

1 reference

26 September 2017

Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

mitochondrion organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

transcription, DNA-templated

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

mitochondrial respiratory chain complex assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00059

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

26 September 2017

Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

transcription by RNA polymerase II

determination method

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00059&geneProductId=UniProtKB:Q00059

determination method

High mobility group box domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00059

Identifiers

MeSH descriptor ID

subject named as

mitochondrial transcription factor A

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363002

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363002

ENSP00000420588

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420588

ENSP00000378776

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378776

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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