Palmitoyl-protein thioesterase 1 (Q21134385)

http://www.ebi.ac.uk/interpro/protein/P50897

Alpha/Beta hydrolase fold

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P50897

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

1 reference

13 November 2019

palmitoyl hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

palmitoyl-(protein) hydrolase activity

7 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

palmitoyl-(protein) hydrolase activity

IDA

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain

IDA

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

26 September 2017

Palmitoyl protein thioesterase 1 is targeted to the axons in neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

1 reference

26 September 2017

Palmitoyl protein thioesterase 1 is targeted to the axons in neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

negative regulation of neuron apoptotic process

HDA

biological process

positive regulation of pinocytosis

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

positive regulation of receptor-mediated endocytosis

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

lysosomal lumen acidification

1 reference

8 April 2019

Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

negative regulation of apoptotic process

TAS

1 reference

8 April 2019

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

receptor-mediated endocytosis

IDA

1 reference

26 September 2017

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

nervous system development

1 reference

26 September 2017

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase

lipid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

membrane raft organization

1 reference

8 April 2019

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

protein catabolic process

1 reference

8 April 2019

Batten's disease: clues to neuronal protein catabolism in lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

sphingolipid catabolic process

NAS

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

negative regulation of cell growth

TAS

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

protein depalmitoylation

4 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

26 September 2017

In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

1 reference

8 April 2019

Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

regulation of synapse structure or activity

1 reference

8 April 2019

Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

fatty-acyl-CoA biosynthetic process

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

chemical synaptic transmission

TAS

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

IBA

protein depalmitoylation

6 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

IBA

lysosome organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

neurotransmitter secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

adult locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

regulation of phospholipase A2 activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897

cellular macromolecule catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897