Eukaryotic translation initiation factor 2 subunit alpha (Q21132803)

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mammalian protein found in Homo sapiens

eukaryotic translation initiation factor 2 subunit 1
eIF-2-alpha
EIF2S1
eIF-2alpha
eIF-2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Language	Label	Description	Also known as
English	Eukaryotic translation initiation factor 2 subunit alpha	mammalian protein found in Homo sapiens	eukaryotic translation initiation factor 2 subunit 1 eIF-2-alpha EIF2S1 eIF-2alpha eIF-2A eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Statements

1 reference

13 November 2019

UniProt protein ID

Translation initiation factor 2, alpha subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

Translation initiation factor 2, alpha subunit, middle domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

Translation initiation factor 2, alpha subunit, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

Nucleic acid-binding, OB-fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

RNA-binding domain, S1, protein family

1 reference

based on heuristic

inferred from protein domain or family

S1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

translation initiation factor activity

determination method

4 references

17 October 2017

Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

An efficient mammalian cell-free translation system supplemented with translation factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

ribosome binding

determination method

1 reference

17 October 2017

The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

protein binding

determination method

9 references

8 April 2019

The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

4 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

translation initiation factor activity

determination method

5 references

8 April 2019

Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

An efficient mammalian cell-free translation system supplemented with translation factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

eukaryotic 48S preinitiation complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

8 April 2019

Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

multi-eIF complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

eukaryotic translation initiation factor 2B complex

determination method

1 reference

17 October 2017

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05198&geneProductId=UniProtKB:P05198

determination method

glial limiting end-foot

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

translation initiation ternary complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

cytoplasmic stress granule

determination method

extracellular exosome

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

eukaryotic translation initiation factor 2 complex

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

eukaryotic translation initiation factor 2B complex

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

biological process

cellular response to heat

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

positive regulation of type B pancreatic cell apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

response to endoplasmic reticulum stress

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

response to manganese-induced endoplasmic reticulum stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

transmembrane transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

regulation of translation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

regulation of translational initiation in response to stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

negative regulation of guanyl-nucleotide exchange factor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

PERK-mediated unfolded protein response

determination method

1 reference

8 April 2019

The endoplasmic reticulum stress response in aging and age-related diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05198

determination method

RNA-binding domain, S1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05198

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000256383

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000256383

ENSP00000425299

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425299

ENSP00000451975

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451975

ENSP00000452034

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452034

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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