Mitotic arrest deficient 2 like 1 (Q21132390)

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mammalian protein found in Homo sapiens
  • mitotic spindle assembly checkpoint protein MAD2A
  • MAD2 mitotic arrest deficient-like 1
  • MAD2-like protein 1
  • mitotic arrest deficient, yeast, homolog-like 1
  • MAD2L1
  • MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
  • mitotic arrest deficient 2-like protein 1
edit
Language Label Description Also known as
English
Mitotic arrest deficient 2 like 1
mammalian protein found in Homo sapiens
  • mitotic spindle assembly checkpoint protein MAD2A
  • MAD2 mitotic arrest deficient-like 1
  • MAD2-like protein 1
  • mitotic arrest deficient, yeast, homolog-like 1
  • MAD2L1
  • MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
  • mitotic arrest deficient 2-like protein 1

Statements

molecular function
protein binding
determination method
IPI
41 references
retrieved
9 May 2019
stated in
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Disruption of FAT10-MAD2 binding inhibits tumor progression.
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
p31comet blocks Mad2 activation through structural mimicry
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
The influence of catalysis on mad2 activation dynamics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
p31comet blocks Mad2 activation through structural mimicry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
A protein domain-based interactome network for C. elegans early embryogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IPI
cell component
kinetochore
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IEA
retrieved
8 April 2019
stated in
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
8 April 2019
stated in
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
8 April 2019
stated in
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
8 April 2019
stated in
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
kinetochore
determination method
IBA
IDA
IEA
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IEA
retrieved
9 May 2019
stated in
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
9 May 2019
stated in
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
9 May 2019
stated in
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
9 May 2019
stated in
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
GOA
curator
UniProt
UniProt protein ID
Q13257
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13257
determination method
IBA
biological process

Identifiers

 
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