The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A (Q21131379)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23675303%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A (English)

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1 March 2020

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1 reference

1 reference

8

Ralf Bartenschlager

Ralf

Bartenschlager

1 reference

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1 March 2020

3

Inés Romero-Brey

Inés

Romero-Brey

1 reference

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1 March 2020

6

Alessia Ruggieri

Alessia

Ruggieri

1 reference

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1 March 2020

9

Volker Lohmann

Volker

Lohmann

1 reference

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1 March 2020

Simon Reiss

1

Simon

Reiss

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1 March 2020

Christian Harak

2

Christian

Harak

1 reference

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1 March 2020

Danijela Radujkovic

4

Danijela

Radujkovic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23675303%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Rahel Klein

5

Rahel

Klein

1 reference

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1 March 2020

Ilka Rebhan

7

Ilka

Rebhan

1 reference

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1 March 2020

language of work or name

English

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publication date

9 May 2013

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1 March 2020

1 reference

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1 March 2020

volume

9

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1 March 2020

issue

5

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1 March 2020

page(s)

e1003359

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Creative Commons Attribution 4.0 International

1 March 2020

copyright license

start time

9 May 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

SQL

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26 June 2022

https://europepmc.org/article/PMC/PMC3649985

based on heuristic

inferred from PubMed Central ID database lookup

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Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

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19 March 2017

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19 March 2017

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7 April 2017

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10 May 2017

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Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion.

12 September 2017

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12 September 2017

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ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication

12 September 2017

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The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement

12 September 2017

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Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.

12 September 2017

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Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052

12 September 2017

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Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein

12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

12 September 2017

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Role of annexin A2 in the production of infectious hepatitis C virus particles

27 September 2017

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Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

27 September 2017

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Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

27 September 2017

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A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

27 September 2017

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Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

27 September 2017

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Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A.

27 September 2017

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Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture

27 September 2017

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The NS5A protein of hepatitis C virus is a zinc metalloprotein

27 September 2017

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Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.

27 September 2017

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Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3649985

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3649985

Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3649985

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3649985

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3649985

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1003359

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1003359

Structural biology of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1003359

Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1003359

Characterization of Recombinant Phosphatidylinositol 4-Kinase β Reveals Auto- and Heterophosphorylation of the Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1003359

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23675303

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1003359

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23675303%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23675303%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23675303%20AND%20SRC:MED&resulttype=core&format=json