The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication (Q27481029)

6

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Charles M. Rice

7

object named as

Charles M Rice

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Brett Lindenbach

1

object named as

Brett D Lindenbach

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author name string

Béla M Prágai

2

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Rudolf K F Beran

4

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Anna M Pyle

The Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation

5

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publication date

September 2007

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published in

Journal of Virology

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volume

81

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page(s)

8905-18

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issue

17

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cites work

1 reference

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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

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Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

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Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

20 March 2017

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

20 March 2017

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Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

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Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells

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Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

20 March 2017

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Solution structure and dynamics of Crh, the Bacillus subtilis catabolite repression HPr

20 March 2017

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The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

20 March 2017

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Involvement of electrostatic interactions in the mechanism of peptide folding induced by sodium dodecyl sulfate binding

20 March 2017

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Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines

20 March 2017

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

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Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B

20 March 2017

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Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

20 March 2017

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The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins

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Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR

20 March 2017

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The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation

20 March 2017

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

20 March 2017

1 reference

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Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

20 March 2017

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Kinetic and structural analyses of hepatitis C virus polyprotein processing

20 March 2017

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Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase

20 March 2017

1 reference

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Hepatitis C virus polyprotein processing: kinetics and mutagenic analysis of serine proteinase-dependent cleavage

20 March 2017

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Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing

20 March 2017

1 reference

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Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli

20 March 2017

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Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

20 March 2017

1 reference

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A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

20 March 2017

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Complete replication of hepatitis C virus in cell culture

20 March 2017

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20 March 2017

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Efficient initiation of HCV RNA replication in cell culture

20 March 2017

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The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data

20 March 2017

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

20 March 2017

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

20 March 2017

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Novel insights into hepatitis C virus replication and persistence

7 April 2017

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Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

7 April 2017

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7 April 2017

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Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

7 April 2017

1 reference

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Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis

29 September 2017

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29 September 2017

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From structure to function: new insights into hepatitis C virus RNA replication

29 September 2017

1 reference

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The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others

29 September 2017

1 reference

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Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

29 September 2017

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Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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'Random coil' 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951449

Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

29 September 2017

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Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus

2 June 2018

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Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus

2 June 2018

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Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1951449

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

2 June 2018

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Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.

2 June 2018

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2 June 2018

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Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.

2 June 2018

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Structural biology of hepatitis C virus

27 November 2018

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Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons

27 November 2018

1 reference

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Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo

27 November 2018

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Substrate specificity of the NS3 serine proteinase of hepatitis C virus as determined by mutagenesis at the NS3/NS4A junction

27 November 2018

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Quantitative determination of helical propensities from trifluoroethanol titration curves

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17581983

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Los Alamos Hepatitis C Immunology Database

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PubMed

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