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RAN, member RAS oncogene family (Q21130500)

From Wikidata
mammalian protein found in Homo sapiens
  • androgen receptor-associated protein 24
  • RAN
  • GTPase Ran
  • guanosine triphosphatase Ran
  • ras-related nuclear protein
  • ras-like protein TC4
  • RanGTPase
  • OK/SW-cl.81
  • GTP-binding nuclear protein Ran
  • member RAS oncogene family
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    English
    RAN, member RAS oncogene family
    mammalian protein found in Homo sapiens
    • androgen receptor-associated protein 24
    • RAN
    • GTPase Ran
    • guanosine triphosphatase Ran
    • ras-related nuclear protein
    • ras-like protein TC4
    • RanGTPase
    • OK/SW-cl.81
    • GTP-binding nuclear protein Ran
    • member RAS oncogene family

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    32 references
    retrieved
    8 April 2019
    stated in
    NTF2 mediates nuclear import of Ran.
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A survivin-ran complex regulates spindle formation in tumor cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A new role for nuclear transport factor 2 and Ran: nuclear import of CapG
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity.
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural determinants and mechanism of mammalian CRM1 allostery
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Artificial nanopores that mimic the transport selectivity of the nuclear pore complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for the nuclear export activity of Importin13
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A giant nucleopore protein that binds Ran/TC4
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human RanBP3, a group of nuclear RanGTP binding proteins1
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification and characterization of the human MOG1 gene
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IPI
    GTP binding
    determination method or standard
    IEA
    IDA
    IMP
    8 references
    retrieved
    8 April 2019
    stated in
    The F-actin filament capping protein CapG is a bona fide nucleolar protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    GTPase activity
    determination method or standard
    IBA
    IDA
    IEA
    TAS
    6 references
    retrieved
    8 April 2019
    stated in
    The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy
    GOA
    curator
    UniProt
    UniProt protein ID
    P62826
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
    determination method or standard
    IBA
    cell component
    biological process

    Identifiers

    PDB structure ID
     
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