RAN, member RAS oncogene family (Q21130500)

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mammalian protein found in Homo sapiens
  • androgen receptor-associated protein 24
  • RAN
  • GTPase Ran
  • guanosine triphosphatase Ran
  • ras-related nuclear protein
  • ras-like protein TC4
  • RanGTPase
  • OK/SW-cl.81
  • GTP-binding nuclear protein Ran
  • member RAS oncogene family
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Language Label Description Also known as
English
RAN, member RAS oncogene family
mammalian protein found in Homo sapiens
  • androgen receptor-associated protein 24
  • RAN
  • GTPase Ran
  • guanosine triphosphatase Ran
  • ras-related nuclear protein
  • ras-like protein TC4
  • RanGTPase
  • OK/SW-cl.81
  • GTP-binding nuclear protein Ran
  • member RAS oncogene family

Statements

molecular function
protein binding
determination method
IPI
32 references
retrieved
8 April 2019
stated in
NTF2 mediates nuclear import of Ran.
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A survivin-ran complex regulates spindle formation in tumor cells
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A new role for nuclear transport factor 2 and Ran: nuclear import of CapG
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity.
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Structural determinants and mechanism of mammalian CRM1 allostery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Artificial nanopores that mimic the transport selectivity of the nuclear pore complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the nuclear export activity of Importin13
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A giant nucleopore protein that binds Ran/TC4
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Human RanBP3, a group of nuclear RanGTP binding proteins
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of the human MOG1 gene
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IPI
GTP binding
determination method
IEA
IDA
IMP
8 references
retrieved
8 April 2019
stated in
The F-actin filament capping protein CapG is a bona fide nucleolar protein
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IEA
retrieved
8 April 2019
stated in
Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
retrieved
8 April 2019
stated in
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
retrieved
8 April 2019
stated in
Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
retrieved
8 April 2019
stated in
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
GTPase activity
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IEA
retrieved
8 April 2019
stated in
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
retrieved
8 April 2019
stated in
Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy
GOA
curator
UniProt
UniProt protein ID
P62826
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62826
determination method
IBA
cell component
biological process

Identifiers

PDB structure ID
 
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