PIN2 (TERF1) interacting telomerase inhibitor 1 (Q21123260)

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mammalian protein found in Homo sapiens
  • pin2-interacting protein X1
  • protein 67-11-3
  • PINX1
  • PIN2/TERF1-interacting telomerase inhibitor 1
  • hepatocellular carcinoma-related putative tumor suppressor
  • liver-related putative tumor suppressor
  • TRF1-interacting protein 1
  • 67-11-3 protein
  • PIN2-interacting protein 1
  • PINX1 protein, human
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Language Label Description Also known as
English
PIN2 (TERF1) interacting telomerase inhibitor 1
mammalian protein found in Homo sapiens
  • pin2-interacting protein X1
  • protein 67-11-3
  • PINX1
  • PIN2/TERF1-interacting telomerase inhibitor 1
  • hepatocellular carcinoma-related putative tumor suppressor
  • liver-related putative tumor suppressor
  • TRF1-interacting protein 1
  • 67-11-3 protein
  • PIN2-interacting protein 1
  • PINX1 protein, human

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR
GOA
curator
UniProt
UniProt protein ID
Q96BK5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression
GOA
curator
UniProt
UniProt protein ID
Q96BK5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
retrieved
8 April 2019
stated in
Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IPI
cell component
nucleolus
determination method
IEA
IDA
NAS
8 references
retrieved
8 April 2019
stated in
Increased Stability of Nucleolar PinX1 in the Presence of TERT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96BK5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IEA
retrieved
8 April 2019
stated in
PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression
GOA
curator
UniProt
UniProt protein ID
Q96BK5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
retrieved
8 April 2019
stated in
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
retrieved
8 April 2019
stated in
Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
retrieved
8 April 2019
stated in
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
retrieved
8 April 2019
stated in
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
retrieved
8 April 2019
stated in
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BK5
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
C440808
subject named as
PINX1 protein, human
0 references
 
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