Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (Q21120060)

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mammalian protein found in Homo sapiens

MTHFD2
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase

Language	Label	Description	Also known as
English	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	mammalian protein found in Homo sapiens	MTHFD2 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase

Statements

1 reference

13 November 2019

UniProt protein ID

NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

methenyltetrahydrofolate cyclohydrolase activity

determination method

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

magnesium ion binding

determination method

2 references

8 April 2019

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

methylenetetrahydrofolate dehydrogenase (NADP+) activity

determination method

3 references

26 September 2017

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

phosphate ion binding

determination method

2 references

8 April 2019

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

methylenetetrahydrofolate dehydrogenase (NADP+) activity

determination method

4 references

8 April 2019

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

methenyltetrahydrofolate cyclohydrolase activity

determination method

3 references

8 April 2019

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method

4 references

8 April 2019

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

determination method

4 references

26 September 2017

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

mitochondrial matrix

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

extracellular space

determination method

1 reference

26 September 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

extracellular space

determination method

1 reference

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

tetrahydrofolate metabolic process

determination method

1 reference

26 September 2017

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method

folic acid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

one-carbon metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

tetrahydrofolate interconversion

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method

tetrahydrofolate metabolic process

determination method

Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13995

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000377617

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377617

ENSP00000386536

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386536

ENSP00000386542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386542

ENSP00000419067

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419067

ENSP00000419550

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419550

PDB structure ID

1 reference

6 January 2016

http://www.uniprot.org/uniprot/P13995.txt?version=168

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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