NOP53 ribosome biogenesis factor (Q21119018)

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mammalian protein found in Homo sapiens

NOP53
glioma tumor suppressor candidate region gene 2 protein
p60
ribosome biogenesis protein NOP53
protein interacting with carboxyl terminus 1
GLTSCR2

Language	Label	Description	Also known as
English	NOP53 ribosome biogenesis factor	mammalian protein found in Homo sapiens	NOP53 glioma tumor suppressor candidate region gene 2 protein p60 ribosome biogenesis protein NOP53 protein interacting with carboxyl terminus 1 GLTSCR2

Statements

1 reference

13 November 2019

UniProt protein ID

Ribosome biogenesis protein Nop53/GLTSCR2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZM5

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

5S rRNA binding

determination method

1 reference

26 September 2017

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

determination method

protein binding

determination method

10 references

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

identical protein binding

determination method

1 reference

8 April 2019

The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

10 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

1 reference

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

fibrillar center

determination method

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

rDNA heterochromatin

determination method

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

biological process

ribosomal large subunit assembly

determination method

1 reference

26 September 2017

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

determination method

regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

protein stabilization

determination method

1 reference

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

regulation of signal transduction by p53 class mediator

determination method

4 references

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

regulation of aerobic respiration

determination method

1 reference

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

ribosomal large subunit export from nucleus

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

determination method

1 reference

8 April 2019

Involvement of GLTSCR2 in the DNA Damage Response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

mitotic G2 DNA damage checkpoint signaling

determination method

1 reference

8 April 2019

Involvement of GLTSCR2 in the DNA Damage Response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of protein-containing complex assembly

determination method

1 reference

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

3 references

8 April 2019

GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

regulation of apoptotic process

determination method

1 reference

8 April 2019

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

regulation of cell cycle

determination method

1 reference

8 April 2019

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

cellular response to hypoxia

determination method

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

protein localization to nucleolus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

regulation of RIG-I signaling pathway

determination method

1 reference

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

determination method

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

positive regulation of protein K63-linked deubiquitination

determination method

1 reference

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

ribosome biogenesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

rRNA processing

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000246802

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000246802

ENSP00000468948

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468948

ENSP00000470190

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470190

ENSP00000470263

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470263

ENSP00000470773

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470773

Sitelinks

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