Elongation factor Tu GTP binding domain containing 2 (Q21118377)

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mammalian protein found in Homo sapiens

elongation factor Tu GTP-binding domain-containing protein 2
U5 snRNP-specific protein, 116 kDa
SNU114 homolog
116 kDa U5 small nuclear ribonucleoprotein component
EFTUD2
hSNU114
U5-116 kDa

Language	Label	Description	Also known as
English	Elongation factor Tu GTP binding domain containing 2	mammalian protein found in Homo sapiens	elongation factor Tu GTP-binding domain-containing protein 2 U5 snRNP-specific protein, 116 kDa SNU114 homolog 116 kDa U5 small nuclear ribonucleoprotein component EFTUD2 hSNU114 U5-116 kDa

Statements

1 reference

13 November 2019

UniProt protein ID

EF-G domain III/V-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

Ribosomal protein S5 domain 2-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

Ribosomal protein S5 domain 2-type fold, subgroup

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

Translation protein, beta-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

Elongation factor EFG, domain V-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Translation elongation factor EFTu-like, domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

116kDa U5 small nuclear ribonucleoprotein component, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

116kDa U5 small nuclear ribonucleoprotein component, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Translation elongation factor EFG/EF2, domain IV, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor, GTP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

determination method

2 references

protein binding

determination method

6 references

8 April 2019

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

GTPase activity

determination method

3 references

1 January 2018

An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

U5 snRNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

8 April 2019

RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

catalytic step 2 spliceosome

determination method

1 reference

8 April 2019

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15029&geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

extracellular matrix

determination method

1 reference

26 September 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15029&geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15029&geneProductId=UniProtKB:Q15029

determination method

U4/U6 x U5 tri-snRNP complex

determination method

1 reference

26 September 2017

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15029&geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

U4/U6 x U5 tri-snRNP complex

determination method

ribonucleoprotein complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

spliceosomal complex

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

U2-type precatalytic spliceosome

determination method

1 reference

8 April 2019

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

biological process

response to cocaine

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

mRNA splicing, via spliceosome

determination method

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

1 January 2018

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

mRNA splicing, via spliceosome

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

mRNA processing

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15029

determination method

116kDa U5 small nuclear ribonucleoprotein component, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

transcription factor, GTP-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

translation elongation factor EFG/EF2, domain IV

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

elongation factor EFG, domain V-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

small GTP-binding protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

translation elongation factor EFTu-like, domain 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

116kDa U5 small nuclear ribonucleoprotein component, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15029

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000385873

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385873

ENSP00000392094

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392094

ENSP00000465058

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465058

ENSP00000467805

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467805

ENSP00000464882

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464882

ENSP00000464908

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464908

ENSP00000465051

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465051

ENSP00000467249

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467249

ENSP00000467639

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467639

ENSP00000468284

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468284

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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