X-ray repair cross complementing 6 (Q21116645)

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mammalian protein found in Homo sapiens
  • CTC box binding factor 75 kDa subunit
  • Ku autoantigen, 70kDa
  • CTC box-binding factor 75 kDa subunit
  • DNA repair protein XRCC6
  • thyroid autoantigen 70kD (Ku antigen)
  • ATP-dependent DNA helicase II 70 kDa subunit
  • CTCBF
  • ATP-dependent DNA helicase II, 70 kDa subunit
  • 5'-deoxyribose-5-phosphate lyase Ku70
  • 70 kDa subunit of Ku antigen
  • X-ray repair cross-complementing protein 6
  • lupus Ku autoantigen protein p70
  • 5'-dRP lyase Ku70
  • TLAA
  • X-ray repair complementing defective repair in Chinese hamster cells 6
  • Ku autoantigen p70 subunit
  • thyroid-lupus autoantigen p70
  • ATP-dependent DNA helicase 2 subunit 1
  • Ku70
  • thyroid autoantigen 70kDa (Ku antigen)
  • XRCC6
  • CTC75
  • Thyroid-lupus autoantigen
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa), isoform CRA_a
  • Xrcc6 protein, human
edit
Language Label Description Also known as
English
X-ray repair cross complementing 6
mammalian protein found in Homo sapiens
  • CTC box binding factor 75 kDa subunit
  • Ku autoantigen, 70kDa
  • CTC box-binding factor 75 kDa subunit
  • DNA repair protein XRCC6
  • thyroid autoantigen 70kD (Ku antigen)
  • ATP-dependent DNA helicase II 70 kDa subunit
  • CTCBF
  • ATP-dependent DNA helicase II, 70 kDa subunit
  • 5'-deoxyribose-5-phosphate lyase Ku70
  • 70 kDa subunit of Ku antigen
  • X-ray repair cross-complementing protein 6
  • lupus Ku autoantigen protein p70
  • 5'-dRP lyase Ku70
  • TLAA
  • X-ray repair complementing defective repair in Chinese hamster cells 6
  • Ku autoantigen p70 subunit
  • thyroid-lupus autoantigen p70
  • ATP-dependent DNA helicase 2 subunit 1
  • Ku70
  • thyroid autoantigen 70kDa (Ku antigen)
  • XRCC6
  • CTC75
  • Thyroid-lupus autoantigen
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa), isoform CRA_a
  • Xrcc6 protein, human

Statements

part of
molecular function
protein binding
determination method
IPI
43 references
retrieved
1 January 2018
stated in
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
SIRT1 promotes DNA repair activity and deacetylation of Ku70
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Role of the translationally controlled tumor protein in DNA damage sensing and repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A role for the HOXB7 homeodomain protein in DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
A role of DNA-PK for the metabolic gene regulation in response to insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of human Ku70 with TRF2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Human Ku70/80 associates physically with telomerase through interaction with hTERT
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
retrieved
1 January 2018
stated in
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IPI
cell component
biological process
double-strand break repair via nonhomologous end joining
determination method
IEA
IMP
TAS
6 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
31 October 2017
stated in
Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
31 October 2017
stated in
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
31 October 2017
stated in
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
IMP
retrieved
31 October 2017
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
IMP
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12956&geneProductId=UniProtKB:P12956
determination method
IEA
double-strand break repair via nonhomologous end joining
determination method
IBA
IEA
IMP
TAS
7 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
1 January 2018
stated in
Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
1 January 2018
stated in
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
TAS
retrieved
1 January 2018
stated in
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IMP
retrieved
1 January 2018
stated in
Heat shock factor 1, an inhibitor of non-homologous end joining repair
GOA
curator
UniProt
UniProt protein ID
P12956
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IEA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12956
determination method
IBA

Identifiers

MeSH descriptor ID
C000606509
subject named as
Xrcc6 protein, human
0 references
 
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