sirtuin 1 (Q21113719)

DHS-like NAD/FAD-binding domain superfamily

1 reference

Sirtuin, catalytic core small domain superfamily

1 reference

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

transcription corepressor activity

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

protein domain specific binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

core promoter sequence-specific DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

protein C-terminus binding

1 reference

1 January 2018

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

keratin filament binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

transcription factor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

protein deacetylase activity

7 references

1 January 2018

SIRT1 regulates UV-induced DNA repair through deacetylating XPA

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

66 references

1 January 2018

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

DBC1 is a negative regulator of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

HDAC3 is negatively regulated by the nuclear protein DBC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates UV-induced DNA repair through deacetylating XPA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

DBC1 is a negative regulator of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Novel repressor regulates insulin sensitivity through interaction with Foxo1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Global landscape of HIV-human protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 promotes DNA repair activity and deacetylation of Ku70

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

AROS has a context-dependent effect on SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 links CIITA deacetylation to MHC II activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Negative regulation of the deacetylase SIRT1 by DBC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Epigenetic control of rDNA loci in response to intracellular energy status

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 negatively regulates the mammalian target of rapamycin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

NAD-dependent histone deacetylase activity

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

NAD-dependent protein deacetylase activity

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

mitogen-activated protein kinase binding

1 reference

1 January 2018

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

bHLH transcription factor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

identical protein binding

1 reference

1 January 2018

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

NAD+ ADP-ribosyltransferase activity

1 reference

1 January 2018

Sirtuin functions in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

Epigenetic control of rDNA loci in response to intracellular energy status

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

chromatin silencing complex

1 reference

1 January 2018

Epigenetic control of rDNA loci in response to intracellular energy status

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

nuclear inner membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of MHC class II biosynthetic process

biological process

1 reference

1 January 2018

SIRT1 links CIITA deacetylation to MHC II activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

single strand break repair

1 reference

1 January 2018

Role of SIRT1 in homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

muscle organ development

1 reference

1 January 2018

histone H3-K9 deacetylation

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of cellular response to testosterone stimulus

1 reference

1 January 2018

Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

cellular response to DNA damage stimulus

1 reference

1 January 2018

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

1 January 2018

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

DNA methylation-dependent heterochromatin assembly

1 reference

1 January 2018

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of cellular senescence

1 reference

1 January 2018

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of helicase activity

1 reference

1 January 2018

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

cellular response to hypoxia

1 reference

1 January 2018

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

peptidyl-lysine deacetylation

1 reference

1 January 2018

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of peptidyl-lysine acetylation

1 reference

1 January 2018

SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of transcription, DNA-templated

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of adaptive immune response

1 reference

1 January 2018

SIRT1 links CIITA deacetylation to MHC II activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

stress-induced premature senescence

1 reference

1 January 2018

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of androgen receptor signaling pathway

1 reference

1 January 2018

Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

response to oxidative stress

1 reference

1 January 2018

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of DNA-binding transcription factor activity

4 references

1 January 2018

Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of gene expression

transcription, DNA-templated

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of cAMP-dependent protein kinase activity

1 reference

1 January 2018

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

histone H3-K9 modification

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

protein ubiquitination

negative regulation of cell growth

1 reference

1 January 2018

Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of neuron death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of histone H3-K9 methylation

1 reference

1 January 2018

Dynamic distribution of linker histone H1.5 in cellular differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of histone H3-K14 acetylation

1 reference

1 January 2018

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

ovulation from ovarian follicle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of protein serine/threonine kinase activity

1 reference

1 January 2018

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

Sirtuin functions in health and disease

protein ADP-ribosylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of apoptotic process

negative regulation of transcription by RNA polymerase II

5 references

1 January 2018

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

Dynamic distribution of linker histone H1.5 in cellular differentiation

chromatin organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

1 January 2018

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

circadian regulation of gene expression

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

protein deacetylation

9 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

protein destabilization

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of mitotic cell cycle

1 reference

1 January 2018

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of cAMP-dependent protein kinase activity

positive regulation of insulin receptor signaling pathway

1 reference

1 January 2018

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of transcription, DNA-templated

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Repression of estrogen receptor beta function by putative tumor suppressor DBC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of NF-kappaB transcription factor activity

1 reference

1 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

peptidyl-lysine acetylation

1 reference

1 January 2018

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

response to hydrogen peroxide

1 reference

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

1 January 2018

SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of histone H4-K16 acetylation

1 reference

1 January 2018

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of endothelial cell proliferation

1 reference

1 January 2018

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

behavioral response to starvation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

cellular response to tumor necrosis factor

1 reference

1 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of DNA repair

1 reference

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

multicellular organism development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of cell population proliferation

1 reference

1 January 2018

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of cell population proliferation

1 reference

1 January 2018

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of endodeoxyribonuclease activity

1 reference

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

regulation of cellular response to heat

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

1 January 2018

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

UV-damage excision repair

1 reference

1 January 2018

SIRT1 regulates UV-induced DNA repair through deacetylating XPA

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

histone deacetylation

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of transcription by RNA polymerase II

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Multiple tumor suppressor pathways negatively regulate telomerase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

transcription by RNA polymerase II

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of smooth muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of histone H3-K9 trimethylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of apoptotic process

3 references

1 January 2018

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

cellular response to hydrogen peroxide

1 reference

1 January 2018

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of protein acetylation

regulation of apoptotic process

1 reference

1 January 2018

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

cellular response to leukemia inhibitory factor

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of angiogenesis

4 references

1 January 2018

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

Vascular importance of the miR-212/132 cluster.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

1 January 2018

MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

transforming growth factor beta receptor signaling pathway

1 reference

1 January 2018

MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

positive regulation of blood vessel endothelial cell migration

1 reference

1 January 2018

MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6

negative regulation of cellular senescence

physically interacts with

SRT1720

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7703

Sirtuin family, catalytic core domain

English

retrieved

17 August 2016

has part(s)

1 reference

D08.811.277.087.520.200.650.100

Identifiers

MeSH descriptor ID

D056564

subject named as

Sirtuin 1

0 references

MeSH tree code

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference