PTEN induced kinase 1 (Q21112306)

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mammalian protein found in Homo sapiens
  • protein kinase BRPK
  • PINK1
  • PTEN induced putative kinase 1
  • PTEN-induced putative kinase protein 1
  • BRPK
  • serine/threonine-protein kinase PINK1, mitochondrial
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Language Label Description Also known as
English
PTEN induced kinase 1
mammalian protein found in Homo sapiens
  • protein kinase BRPK
  • PINK1
  • PTEN induced putative kinase 1
  • PTEN-induced putative kinase protein 1
  • BRPK
  • serine/threonine-protein kinase PINK1, mitochondrial

Statements

molecular function
protein serine/threonine kinase activity
determination method
IDA
ISS
TAS
IEA
9 references
retrieved
27 February 2018
stated in
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
TAS
retrieved
27 February 2018
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
ISS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Ubiquitin is phosphorylated by PINK1 to activate parkin
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
protein binding
determination method
IPI
12 references
retrieved
27 February 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
retrieved
27 February 2018
stated in
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IPI
cell component
cytosol
determination method
IDA
TAS
IEA
8 references
retrieved
27 February 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
TAS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
mitochondrion
determination method
IDA
IGI
IEA
IMP
11 references
retrieved
27 February 2018
stated in
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IMP
retrieved
27 February 2018
stated in
Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IGI
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
PINK1 protein in normal human brain and Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
biological process
protein phosphorylation
determination method
IDA
TAS
IMP
IEA
7 references
retrieved
27 February 2018
stated in
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
TAS
retrieved
27 February 2018
stated in
PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IMP
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IEA
retrieved
27 February 2018
stated in
BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
GOA
curator
UniProt
UniProt protein ID
Q9BXM7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA
retrieved
27 February 2018
stated in
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7
determination method
IDA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21112306&oldid=2022949316"