CASC3 exon junction complex subunit (Q21110543)

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mammalian protein found in Homo sapiens

metastatic lymph node gene 51 protein
cancer susceptibility candidate 3
CASC3
cancer susceptibility 3
MLN 51
barentsz
protein CASC3
Btz
cancer susceptibility candidate gene 3 protein
metastatic lymph node 51
protein barentsz

Language	Label	Description	Also known as
English	CASC3 exon junction complex subunit	mammalian protein found in Homo sapiens	metastatic lymph node gene 51 protein cancer susceptibility candidate 3 CASC3 cancer susceptibility 3 MLN 51 barentsz protein CASC3 Btz cancer susceptibility candidate gene 3 protein metastatic lymph node 51 protein barentsz

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15234

P-P-bond-hydrolysis-driven transporter

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Btz domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

11 references

8 April 2019

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Disassembly of exon junction complexes by PYM

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

identical protein binding

determination method

1 reference

8 April 2019

Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

4 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

nuclear membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

cytoplasmic stress granule

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

exon-exon junction complex

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

cytoplasmic ribonucleoprotein granule

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

ribonucleoprotein complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

U2-type catalytic step 1 spliceosome

determination method

1 reference

8 April 2019

Structure of a human catalytic step I spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

spliceosomal complex

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

intracellular mRNA localization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

regulation of translation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

mRNA splicing, via spliceosome

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

RNA export from nucleus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

termination of RNA polymerase II transcription

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

mRNA export from nucleus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

mRNA 3'-end processing

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15234&geneProductId=UniProtKB:O15234

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15234

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15234

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264645

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264645

ENSP00000462713

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462713

ENSP00000464626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464626

ENSP00000467654

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467654

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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