Pre-mRNA processing factor 8 (Q21108689)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

pre-mRNA-processing-splicing factor 8
PRP8 pre-mRNA processing factor 8 homolog
U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
PRPF8
precursor mRNA processing protein
p220
apoptosis-regulated protein 1
PRP8 homolog
apoptosis-regulated protein 2
splicing factor Prp8
220 kDa U5 snRNP-specific protein

Language	Label	Description	Also known as
English	Pre-mRNA processing factor 8	mammalian protein found in Homo sapiens	pre-mRNA-processing-splicing factor 8 PRP8 pre-mRNA processing factor 8 homolog U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p PRPF8 precursor mRNA processing protein p220 apoptosis-regulated protein 1 PRP8 homolog apoptosis-regulated protein 2 splicing factor Prp8 220 kDa U5 snRNP-specific protein

Statements

1 reference

13 November 2019

UniProt protein ID

Pre-mRNA-processing-splicing factor 8

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

Ribonuclease H-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

RNA recognition motif, spliceosomal PrP8, protein family

1 reference

based on heuristic

inferred from protein domain or family

PROCT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PRP8 domain IV core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PRO8NT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PROCN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MPN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

JAB1/MPN/MOV34 metalloenzyme domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

K63-linked polyubiquitin modification-dependent protein binding

determination method

1 reference

8 April 2019

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

protein binding

determination method

8 references

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Death by splicing: tumor suppressor RBM5 freezes splice-site pairing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

4 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

second spliceosomal transesterification activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

U1 snRNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

U2 snRNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

pre-mRNA intronic binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

catalytic step 2 spliceosome

determination method

1 reference

17 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

1 reference

17 October 2017

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

small nuclear ribonucleoprotein complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

U4/U6 x U5 tri-snRNP complex

determination method

1 reference

8 April 2019

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

U2-type precatalytic spliceosome

determination method

1 reference

8 April 2019

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

U2-type catalytic step 2 spliceosome

determination method

1 reference

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

biological process

mRNA splicing, via spliceosome

determination method

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

17 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

spliceosomal tri-snRNP complex assembly

determination method

1 reference

17 October 2017

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P2Q9&geneProductId=UniProtKB:Q6P2Q9

determination method

RNA splicing, via transesterification reactions

determination method

1 reference

8 April 2019

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

cellular response to lipopolysaccharide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

mRNA splicing, via spliceosome

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

8 April 2019

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P2Q9

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

PRP8 domain IV core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

JAB1/MPN/MOV34 metalloenzyme domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

RNA recognition motif, spliceosomal PrP8

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P2Q9

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000304350

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000304350

ENSP00000460348

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460348

ENSP00000479194

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479194

ENSP00000488611

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488611

ENSP00000460849

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460849

ENSP00000458151

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458151

ENSP00000459095

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459095

ENSP00000488222

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488222

PDB structure ID

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21108689&oldid=2022934493"