KH RNA binding domain containing, signal transduction associated 1 (Q21108628)

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mammalian protein found in Homo sapiens
  • KH domain containing, RNA binding, signal transduction associated 1
  • src-associated in mitosis 68 kDa protein
  • p21 Ras GTPase-activating protein-associated p62
  • Sam68
  • KH domain-containing, RNA-binding, signal transduction-associated protein 1
  • GAP-associated tyrosine phosphoprotein p62 (Sam68)
  • GAP-associated tyrosine phosphoprotein p62
  • p68
  • KHDRBS1
edit
Language Label Description Also known as
English
KH RNA binding domain containing, signal transduction associated 1
mammalian protein found in Homo sapiens
  • KH domain containing, RNA binding, signal transduction associated 1
  • src-associated in mitosis 68 kDa protein
  • p21 Ras GTPase-activating protein-associated p62
  • Sam68
  • KH domain-containing, RNA-binding, signal transduction-associated protein 1
  • GAP-associated tyrosine phosphoprotein p62 (Sam68)
  • GAP-associated tyrosine phosphoprotein p62
  • p68
  • KHDRBS1

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
9 May 2019
stated in
RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The human SWI/SNF subunit Brm is a regulator of alternative splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The association of Sam68 with Vav1 contributes to tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Functional interaction between c-Src and its mitotic target, Sam 68
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
RNA binding
determination method
IDA
IEA
6 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
17 October 2017
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IDA
retrieved
17 October 2017
stated in
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IDA
retrieved
17 October 2017
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07666&geneProductId=UniProtKB:Q07666
determination method
IDA
identical protein binding
determination method
IDA
IPI
5 references
retrieved
9 May 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IPI
retrieved
9 May 2019
stated in
RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IDA
retrieved
9 May 2019
stated in
T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IDA
RNA binding
determination method
HDA
IBA
IDA
IEA
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IEA
retrieved
9 May 2019
stated in
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
IBA
retrieved
9 May 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
HDA
retrieved
9 May 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q07666
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07666
determination method
HDA
cell component
biological process

Identifiers

 
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