A-kinase anchoring protein 5 (Q21108168)

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mammalian protein found in Homo sapiens

AKAP 79
A-kinase anchor protein 79 kDa
A-kinase anchor protein 5
A kinase (PRKA) anchor protein 5
AKAP5
cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
A-kinase anchoring protein 75/79
H21

Language	Label	Description	Also known as
English	A-kinase anchoring protein 5	mammalian protein found in Homo sapiens	AKAP 79 A-kinase anchor protein 79 kDa A-kinase anchor protein 5 A kinase (PRKA) anchor protein 5 AKAP5 cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein A-kinase anchoring protein 75/79 H21

Statements

1 reference

13 November 2019

UniProt protein ID

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Protein kinase A anchoring, WSK motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein kinase A binding

determination method

1 reference

8 April 2019

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

calmodulin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

protein binding

determination method

8 references

8 April 2019

AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

protein kinase A regulatory subunit binding

determination method

1 reference

3 January 2017

Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P24588

determination method

adenylate cyclase binding

determination method

1 reference

3 January 2017

Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P24588

determination method

adenylate cyclase binding

determination method

SH3 domain binding

determination method

1 reference

8 April 2019

Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

protein phosphatase 2B binding

determination method

1 reference

8 April 2019

Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

beta-2 adrenergic receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

protein kinase A regulatory subunit binding

determination method

GABA receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

scaffold protein binding

determination method

1 reference

8 April 2019

Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

8 April 2019

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

dendrite membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

dendritic spine

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

determination method

1 reference

8 April 2019

Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

excitatory synapse

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

biological process

protein targeting

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

positive regulation of protein kinase A signaling

determination method

1 reference

3 January 2017

Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P24588

determination method

chemical synaptic transmission

determination method

1 reference

8 April 2019

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

negative regulation of adenylate cyclase activity

determination method

regulation of protein kinase A signaling

determination method

1 reference

8 April 2019

Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

positive regulation of adenylate cyclase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

positive regulation of protein localization to plasma membrane

determination method

1 reference

8 April 2019

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24588

determination method

Protein kinase A anchoring, WSK motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24588

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000315615

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000315615

ENSP00000378207

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378207

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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