DEAH-box helicase 36 (Q21105799)

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mammalian protein found in Homo sapiens
  • probable ATP-dependent RNA helicase DHX36
  • DHX36
  • DEAH box protein 36
  • MLE-like protein 1
  • RNA helicase associated with AU-rich element ARE
  • RNA helicase associated with AU-rich element protein
  • G4 resolvase-1
  • G4-resolvase 1
  • ATP-dependent RNA helicase DHX36
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36
  • ATP-dependent DNA/RNA helicase DHX36
  • DEAD/H box polypeptide 36
  • DEAH (Asp-Glu-Ala-His) box polypeptide 36
  • G4R1
edit
Language Label Description Also known as
English
DEAH-box helicase 36
mammalian protein found in Homo sapiens
  • probable ATP-dependent RNA helicase DHX36
  • DHX36
  • DEAH box protein 36
  • MLE-like protein 1
  • RNA helicase associated with AU-rich element ARE
  • RNA helicase associated with AU-rich element protein
  • G4 resolvase-1
  • G4-resolvase 1
  • ATP-dependent RNA helicase DHX36
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36
  • ATP-dependent DNA/RNA helicase DHX36
  • DEAD/H box polypeptide 36
  • DEAH (Asp-Glu-Ala-His) box polypeptide 36
  • G4R1

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
retrieved
8 April 2019
stated in
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
retrieved
8 April 2019
stated in
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
retrieved
8 April 2019
stated in
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
retrieved
8 April 2019
stated in
Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IPI
G-quadruplex RNA binding
determination method
IBA
IDA
IMP
11 references
retrieved
8 April 2019
stated in
The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3'-End Processing Following UV-Induced DNA Damage.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IMP
retrieved
8 April 2019
stated in
The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IMP
retrieved
8 April 2019
stated in
Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU).
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Biochemical characterization of G4 quadruplex telomerase RNA unwinding by the RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IBA
DNA helicase activity
determination method
IBA
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IEA
retrieved
8 April 2019
stated in
The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Biochemical characterization of G4 quadruplex telomerase RNA unwinding by the RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IBA
G-quadruplex DNA binding
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IEA
retrieved
8 April 2019
stated in
Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU).
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
cell component
nucleus
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IEA
retrieved
8 April 2019
stated in
Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IBA
biological process
RNA secondary structure unwinding
determination method
IDA
5 references
retrieved
8 April 2019
stated in
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA
retrieved
8 April 2019
stated in
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates
GOA
curator
UniProt
UniProt protein ID
Q9H2U1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2U1
determination method
IDA

Identifiers

 
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