LDL receptor related protein associated protein 1 (Q21097389)

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mammalian protein found in Homo sapiens

RAP
39 kDa receptor-associated protein
LRPAP1
alpha-2-macroglobulin receptor-associated protein
low density lipoprotein receptor-related protein associated protein 1
Low density lipoprotein receptor-related protein-associated protein 1
low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)

Language	Label	Description	Also known as
English	LDL receptor related protein associated protein 1	mammalian protein found in Homo sapiens	RAP 39 kDa receptor-associated protein LRPAP1 alpha-2-macroglobulin receptor-associated protein low density lipoprotein receptor-related protein associated protein 1 Low density lipoprotein receptor-related protein-associated protein 1 low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)

Statements

1 reference

18 July 2018

UniProt protein ID

RAP domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30533

Alpha-2-macroglobulin receptor-associated protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30533

Alpha-2-macroglobulin RAP, domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alpha-2-macroglobulin RAP, domain 3, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alpha-2-macroglobulin RAP, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alpha-2-macroglobulin receptor-associated protein, domain 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

18 July 2018

UniProt protein ID

1 reference

18 July 2018

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

very-low-density lipoprotein particle receptor binding

determination method

1 reference

8 April 2019

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

low-density lipoprotein particle receptor binding

determination method

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30533

determination method

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30533

determination method

3 January 2017

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30533

determination method

3 January 2017

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30533

determination method

protein binding

determination method

4 references

8 April 2019

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

Structural basis for specific recognition of reelin by its receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

receptor antagonist activity

determination method

amyloid-beta binding

determination method

1 reference

8 April 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

receptor antagonist activity

determination method

3 references

8 April 2019

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

low-density lipoprotein particle receptor binding

determination method

5 references

8 April 2019

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

rough endoplasmic reticulum

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

extracellular region

determination method

1 reference

8 April 2019

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

endoplasmic reticulum-Golgi intermediate compartment

determination method

1 reference

8 April 2019

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

cis-Golgi network

determination method

1 reference

8 April 2019

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

plasma membrane

determination method

1 reference

8 April 2019

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

rough endoplasmic reticulum lumen

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

8 April 2019

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

biological process

negative regulation of protein binding

determination method

1 reference

8 April 2019

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

negative regulation of very-low-density lipoprotein particle clearance

determination method

1 reference

8 April 2019

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

negative regulation of amyloid-beta clearance

determination method

1 reference

8 April 2019

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

regulation of receptor-mediated endocytosis

determination method

1 reference

8 April 2019

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

extracellular negative regulation of signal transduction

determination method

1 reference

8 April 2019

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

negative regulation of receptor internalization

determination method

1 reference

8 April 2019

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

negative regulation of cell death

determination method

1 reference

8 April 2019

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

amyloid-beta clearance by transcytosis

determination method

1 reference

8 April 2019

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

positive regulation of amyloid-beta clearance

determination method

1 reference

8 April 2019

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

negative regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30533

determination method

Identifiers

MeSH descriptor ID

subject named as

LDL-Receptor Related Protein-Associated Protein

0 references

D12.776.543.475

0 references

D23.050.422.500.750

0 references

RefSeq protein ID

1 reference

18 May 2018

UniProt protein ID

1 reference

18 July 2018

UniProt protein ID

Ensembl protein ID

ENSP00000421922

1 reference

ensembl Release 93

Ensembl protein ID

ENSP00000421922

ENSP00000421648

1 reference

ensembl Release 93

Ensembl protein ID

ENSP00000421648

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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