Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha (Q21003928)

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English	Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha	scientific article

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Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha (English)

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Ronald M. Evans

3

object named as

Ronald M Evans

author given names

Ronald M

author last names

Evans

1 reference

27 July 2022

author name string

Mei-Fei Yueh

1

author given names

Mei-Fei

author last names

Yueh

1 reference

27 July 2022

Tao Li

2

author given names

Tao

author last names

Li

1 reference

27 July 2022

Bruce Hammock

4

author given names

Bruce

author last names

Hammock

1 reference

27 July 2022

Robert H Tukey

5

author given names

Robert H

author last names

Tukey

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27 July 2022

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publication date

2012

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7

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e37705

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6

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Creative Commons Attribution 4.0 International

15 June 2012

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April 2022 Public Data File from Crossref

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Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects

2 references

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In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens

2 references

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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

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Vitamin D receptor as an intestinal bile acid sensor

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2 references

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

2 references

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Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

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Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro

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The antimicrobial triclocarban stimulates embryo production in the freshwater mudsnail Potamopyrgus antipodarum

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Triclocarban enhances testosterone action: a new type of endocrine disruptor?

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Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

2 references

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Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators

2 references

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

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Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract

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Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue

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Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer

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Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor

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Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus

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A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

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Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells

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Bioaccumulation of triclocarban in Lumbriculus variegatus

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Meta-analysis of mass balances examining chemical fate during wastewater treatment

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Partitioning, persistence, and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment

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Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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Mass loadings of triclosan and triclocarbon from four wastewater treatment plants to three rivers and landfill in Savannah, Georgia, USA.

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Co-occurrence of triclocarban and triclosan in U.S. water resources

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Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

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Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease

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21 January 2018

Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

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The nuclear receptor CAR modulates alcohol-induced liver injury.

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10.1371/JOURNAL.PONE.0037705

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2012PLoSO...737705Y

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