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transcription factor 7 like 2 (Q14913880)

From Wikidata
mammalian protein found in Homo sapiens
  • TCF7L2
  • HMG box transcription factor 4
  • T-cell-specific transcription factor 4
  • T-cell factor 4
  • transcription factor 7-like 2 (T-cell specific, HMG-box)
  • transcription factor 7-like 2
  • TCF-4
  • hTCF-4
  • Transcription Factor 7-Like 2 Protein
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    English
    transcription factor 7 like 2
    mammalian protein found in Homo sapiens
    • TCF7L2
    • HMG box transcription factor 4
    • T-cell-specific transcription factor 4
    • T-cell factor 4
    • transcription factor 7-like 2 (T-cell specific, HMG-box)
    • transcription factor 7-like 2
    • TCF-4
    • hTCF-4
    • Transcription Factor 7-Like 2 Protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    19 references
    retrieved
    1 January 2018
    stated in
    Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure of a human Tcf4-beta-catenin complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The kinase TNIK is an essential activator of Wnt target genes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tcf4 can specifically recognize beta-catenin using alternative conformations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Bcr interferes with beta-catenin-Tcf1 interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9NQB0
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0
    determination method or standard
    IBA
    biological process
    Gene Atlas image
    PBB GE TCF7L2 212759 s at fs.png
    732 × 530; 12 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D058118
    subject named as
    Transcription Factor 7-Like 2 Protein
    0 references
    Ensembl protein ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q14913880&oldid=2383308738"