transcription factor 7 like 2 (Q14913880)

High mobility group box domain superfamily

1 reference

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CTNNB1 binding, N-teminal, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sequence-specific DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

4 references

21 June 2018

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

21 June 2018

MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

21 June 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line

gamma-catenin binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

DNA-binding transcription factor activity

1 reference

21 June 2018

Identification of c-MYC as a target of the APC pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

transcription factor binding

1 reference

1 January 2018

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

1 January 2018

MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

19 references

1 January 2018

Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Structure of a human Tcf4-beta-catenin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

The kinase TNIK is an essential activator of Wnt target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Tcf4 can specifically recognize beta-catenin using alternative conformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Bcr interferes with beta-catenin-Tcf1 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

armadillo repeat domain binding

1 reference

1 January 2018

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

protein kinase binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

1 January 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

5 references

1 January 2018

MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

sequence-specific DNA binding

3 references

1 January 2018

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 reference

1 January 2018

Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

10 September 2018

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

10 September 2018

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

10 September 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

transcription regulator complex

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

positive regulation of heparan sulfate proteoglycan biosynthetic process

biological process

1 reference

1 January 2018

The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

positive regulation of protein kinase B signaling

1 reference

1 January 2018

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

regulation of transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

1 reference

10 September 2018

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

1 reference

1 January 2018

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

ISS

Wnt signaling pathway

regulation of smooth muscle cell proliferation

IEA

2 references

1 reference

1 January 2018

Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

negative regulation of DNA-binding transcription factor activity

1 reference

1 January 2018

A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition

1 reference

1 January 2018

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

positive regulation of protein export from nucleus

IEA

1 reference

1 January 2018

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

maintenance of DNA repeat elements

1 reference

1 January 2018

Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells

blood vessel development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

Inhibition of adipogenesis by Wnt signaling

myoblast fate commitment

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

1 reference

1 January 2018

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

positive regulation of protein binding

TAS

1 reference

1 January 2018

A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

regulation of hormone metabolic process

1 reference

1 January 2018

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

cell population proliferation

1 reference

7 November 2018

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

negative regulation of transcription, DNA-templated

3 references

1 January 2018

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

Inhibition of adipogenesis by Wnt signaling

fat cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

beta-catenin-TCF complex assembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

Wnt signaling pathway, calcium modulating pathway

TAS

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

positive regulation of insulin secretion

TAS

1 reference

10 September 2018

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

negative regulation of transcription by RNA polymerase II

1 reference

27 March 2018

A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

negative regulation of type B pancreatic cell apoptotic process

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

negative regulation of extrinsic apoptotic signaling pathway

ISS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0

positive regulation of transcription by RNA polymerase II

ISS

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

regulation of transcription, DNA-templated

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

regulation of transcription by RNA polymerase II

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Identification of c-MYC as a target of the APC pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

canonical Wnt signaling pathway

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

positive regulation of insulin secretion

positive regulation of epithelial cell proliferation

1 reference

1 January 2018

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0

CTNNB1 binding, N-teminal

Gene Atlas image

PBB GE TCF7L2 212759 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

High mobility group box domain

1 reference

D12.776.660.235.400.800.875

Identifiers

MeSH descriptor ID

D058118

subject named as

Transcription Factor 7-Like 2 Protein

0 references

MeSH tree code

D12.776.260.730.875

0 references

0 references

D12.776.664.235.400.800.875

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata