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Nibrin (Q14911994)

From Wikidata
mammalian protein found in Homo sapiens
  • NBN
  • Nijmegen breakage syndrome protein 1
  • cell cycle regulatory protein p95
  • p95 protein of the MRE11/RAD50 complex
  • Nijmegen breakage syndrome 1 (nibrin)
  • nibrin
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Language Label Description Also known as
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No label defined
    English
    Nibrin
    mammalian protein found in Homo sapiens
    • NBN
    • Nijmegen breakage syndrome protein 1
    • cell cycle regulatory protein p95
    • p95 protein of the MRE11/RAD50 complex
    • Nijmegen breakage syndrome 1 (nibrin)
    • nibrin

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    29 references
    retrieved
    8 April 2019
    stated in
    Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATRX dysfunction induces replication defects in primary mouse cells
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SOSS complexes participate in the maintenance of genomic stability
    GOA
    curator
    UniProt
    UniProt protein ID
    O60934
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Acetyltransferase p300 regulates NBS1-mediated DNA damage response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A divalent FHA/BRCT‐binding mechanism couples the MRE11–RAD50–NBS1 complex to damaged chromatin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDC1 is a mediator of the mammalian DNA damage checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CtIP tetramer assembly is required for DNA-end resection and repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Five dysfunctional telomeres predict onset of senescence in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Notch is a direct negative regulator of the DNA-damage response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SOSS complexes participate in the maintenance of genomic stability
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE NBN 202907 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    C112156
    subject named as
    NBN protein, human
    0 references
     
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