Nibrin (Q14911994)

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mammalian protein found in Homo sapiens
  • NBN
  • Nijmegen breakage syndrome protein 1
  • cell cycle regulatory protein p95
  • p95 protein of the MRE11/RAD50 complex
  • Nijmegen breakage syndrome 1 (nibrin)
  • nibrin
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Language Label Description Also known as
English
Nibrin
mammalian protein found in Homo sapiens
  • NBN
  • Nijmegen breakage syndrome protein 1
  • cell cycle regulatory protein p95
  • p95 protein of the MRE11/RAD50 complex
  • Nijmegen breakage syndrome 1 (nibrin)
  • nibrin

Statements

molecular function
protein binding
determination method
IPI
29 references
retrieved
8 April 2019
stated in
Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
ATRX dysfunction induces replication defects in primary mouse cells
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
SOSS complexes participate in the maintenance of genomic stability
GOA
curator
UniProt
UniProt protein ID
O60934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Acetyltransferase p300 regulates NBS1-mediated DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
MDC1 is a mediator of the mammalian DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of human Mre11: understanding tumorigenic mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
CtIP tetramer assembly is required for DNA-end resection and repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Five dysfunctional telomeres predict onset of senescence in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Notch is a direct negative regulator of the DNA-damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
SOSS complexes participate in the maintenance of genomic stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
retrieved
8 April 2019
stated in
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE NBN 202907 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
C112156
subject named as
NBN protein, human
0 references
 
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