Cryptochrome 1 (photolyase-like) (Q14866013)

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mammalian protein found in Mus musculus
  • Cry1
  • cryptochrome-1
  • uniprot:P97784
edit
Language Label Description Also known as
English
Cryptochrome 1 (photolyase-like)
mammalian protein found in Mus musculus
  • Cry1
  • cryptochrome-1
  • uniprot:P97784

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
10 October 2017
stated in
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Biochemical analysis of the canonical model for the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
The polycomb group protein EZH2 is required for mammalian circadian clock function
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Machine learning helps identify CHRONO as a circadian clock component
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
The BMAL1 C terminus regulates the circadian transcription feedback loop.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
CLOCK-mediated acetylation of BMAL1 controls circadian function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
retrieved
10 October 2017
stated in
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
7 references
retrieved
10 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IEA
retrieved
10 October 2017
stated in
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Large-scale identification of mammalian proteins localized to nuclear sub-compartments
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Functional and structural analyses of cryptochrome. Vertebrate CRY regions responsible for interaction with the CLOCK:BMAL1 heterodimer and its nuclear localization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
biological process
circadian regulation of gene expression
determination method
IGI
IMP
5 references
retrieved
10 October 2017
stated in
Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IGI
regulation of circadian rhythm
determination method
IMP
5 references
retrieved
10 October 2017
stated in
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
retrieved
10 October 2017
stated in
Delay in feedback repression by cryptochrome 1 is required for circadian clock function
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IMP
negative regulation of transcription, DNA-templated
determination method
IDA
IGI
IEA
ISO
12 references
retrieved
10 October 2017
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
ISO
retrieved
10 October 2017
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IGI
retrieved
10 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IEA
retrieved
10 October 2017
stated in
CIPC is a mammalian circadian clock protein without invertebrate homologues
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
The RelB subunit of NFκB acts as a negative regulator of circadian gene expression
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Metastasis-associated protein 1 is an integral component of the circadian molecular machinery
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA
retrieved
10 October 2017
stated in
Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression
GOA
curator
UniProt
UniProt protein ID
P97784
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P97784&geneProductId=UniProtKB:P97784
determination method
IDA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q14866013&oldid=2023062980"