Flavivirus NS4B protein: Structure, function, and antiviral discovery (Q115215932)

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Role of Nonstructural Protein NS2A in Flavivirus Assembly

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Prospects for a dengue virus vaccine

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Inhibition of dengue virus by targeting viral NS4B protein

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Discovery of Dengue Virus NS4B Inhibitors

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dimerization of flavivirus NS4B protein

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Post-translational regulation and modifications of flavivirus structural proteins

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Molecular targets for flavivirus drug discovery

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Restoration of replication-defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The global distribution and burden of dengue

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Progress and Works in Progress: Update on Flavivirus Vaccine Development

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Targeting dengue virus NS4B protein for drug discovery

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

West Nile virus: epidemiology and clinical features of an emerging epidemic in the United States

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Flaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA Capping

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Mutational analysis of the West Nile virus NS4B protein

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Structure and Function of Flavivirus NS5 Methyltransferase

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A structural perspective of the flavivirus life cycle

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The dengue virus NS5 protein as a target for drug discovery

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A single amino acid substitution in the NS4B protein of Dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

West nile virus infections suppress early viral RNA synthesis and avoid inducing the cell stress granule response

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dengue virus NS2 and NS4: Minor proteins, mammoth roles.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Development of antibody-based assays for high throughput discovery and mechanistic study of antiviral agents against yellow fever virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

TMEM41B is a novel regulator of autophagy and lipid mobilization

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

TMEM41B functions with VMP1 in autophagosome formation

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Zika Virus NS2A-Mediated Virion Assembly

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A cocrystal structure of dengue capsid protein in complex of inhibitor

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dengue NS2A Protein Orchestrates Virus Assembly

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The continued threat of emerging flaviviruses

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Recent advances in antiviral drug development towards dengue virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

TMEM41B Is a Pan-flavivirus Host Factor

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Zika Virus Infection Induced Apoptosis by Modulating the Recruitment and Activation of Proapoptotic Protein Bax

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

On track to tackle dengue: History and future of NS4B ligands

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Flavivirus recruits the valosin-containing protein–NPL4 complex to induce stress granule disassembly for efficient viral genome replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Molecular Insights into the Flavivirus Replication Complex

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Inhibition of interferon signaling by dengue virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Flavivirus genome organization, expression, and replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Determinants of Dengue Virus NS4A Protein Oligomerization

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Membrane Topology and Function of Dengue Virus NS2A Protein

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Characterization of dengue virus NS4A and NS4B protein interaction

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Mapping the Interactions between the NS4B and NS3 proteins of dengue virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Systems Biology Reveals NS4B-Cyclophilin A Interaction: A New Target to Inhibit YFV Replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Genomic and epidemiological monitoring of yellow fever virus transmission potential

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

An N-terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Phylogeny of the genus Flavivirus

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

An orthogonal proteomic survey uncovers novel Zika virus host factors

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Mapping Interactions among Cell-Free Expressed Zika Virus Proteins

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

Corona versus Dengue: Distinct Mechanisms for Inhibition of Polyprotein Processing by Antiviral Drugs

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423

A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response

18 November 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2022.105423