The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages (Q102075571)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

title

The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Andrea Vogel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Alexander Lercher

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Marlene Pühringer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Melanie Hofmann

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Markus Kieler

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Martina Kerndl

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Mario Kuttke

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Maria W. Górna

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Marta Kulik

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Paulina M Dominiak

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Martina Schweiger

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Jörg Menche

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Thomas Weichhart

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Mark A Febbraio

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Omar Sharif

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Gernot Schabbauer

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

author name string

Michael Caldera

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Ana Korosec

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Alexander Hajto

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Lucia Quemada Garrido

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Ildiko Mesteri

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Amanda E Brandon

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Emma Estevez

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Casey L Egan

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Florian Gruber

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Andreas Bergthaler

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

Kristaps Klavins

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

publication date

16 November 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

18 November 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Regulation of metabolism by the innate immune system

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Properties and functions of adipose tissue macrophages in obesity

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

A lipase-independent pathway of lipid release and immune modulation by adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

PI3-kinase mutation linked to insulin and growth factor resistance in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Muscle-specific Pten deletion protects against insulin resistance and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Pten positively regulates brown adipose function, energy expenditure, and longevity

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Islet inflammation in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Transcriptional regulation of hepatic lipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Scavenger receptors in atherosclerosis: beyond lipid uptake

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Scavenger receptors in homeostasis and immunity

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

A ceramide-centric view of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Increased CD36 protein as a response to defective insulin signaling in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Role of macrophage scavenger receptors in atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Macrophage Receptor with Collagenous Structure (MARCO) Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis.

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

Circos: an information aesthetic for comparative genomics

1 reference

https://api.crossref.org/works/10.1038%2FS42255-020-00311-5

7 January 2021

10.1038/S42255-020-00311-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33199895%20AND%20SRC:MED&resulttype=core&format=json

18 November 2020

1 reference