Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin (Q92461586)

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29 April 2020

title

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin (English)

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29 April 2020

1

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Daniel Schnepf

2

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29 April 2020

Valentina Bernasconi

6

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29 April 2020

Hans Henrik Gad

7

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29 April 2020

Rune Hartmann

8

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29 April 2020

Peter Staeheli

10

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author name string

Jan Becker

3

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29 April 2020

Karolina Ebert

4

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29 April 2020

Yakup Tanriver

5

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Nils Lycke

9

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publication date

18 March 2019

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29 April 2020

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29 April 2020

volume

20

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issue

5

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page(s)

593-601

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Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

29 April 2020

cites work

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Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

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IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo

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IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

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IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function.

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IFN-λ is able to augment TLR-mediated activation and subsequent function of primary human B cells.

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Type III interferon is a critical regulator of innate antifungal immunity.

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Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

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Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections

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Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

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Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections

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IFN-lambda determines the intestinal epithelial antiviral host defense

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IL-28B is a key regulator of B- and T-cell vaccine responses against influenza

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Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity

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Optimized DNA Vaccine Enhanced by Adjuvant IL28B Induces Protective Immune Responses Against Herpes Simplex Virus Type 2 in Mice

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Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.

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Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

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An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity

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Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice

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Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice

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Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response

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Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

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The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens.

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Follicular Helper T Cells

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Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.

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IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.

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Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses

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7 January 2021

Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection

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Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway.

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Identifiers

DOI

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29 April 2020

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