A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients (Q92260918)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358058%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

title

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients (English)

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28 April 2020

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cognitive dysfunction

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1

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28 April 2020

8

Karen H Ashe

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28 April 2020

author name string

Benjamin R Smith

2

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28 April 2020

Eric S Huang

3

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28 April 2020

Abhishek Mahesh

4

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28 April 2020

Jean Paul G Vonsattel

5

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28 April 2020

Ashley J Petersen

6

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28 April 2020

Rocio Gomez-Pastor

7

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28 April 2020

publication date

30 July 2019

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Acta Neuropathologica Communications

28 April 2020

published in

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28 April 2020

volume

7

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28 April 2020

issue

1

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28 April 2020

page(s)

111

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Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

28 April 2020

cites work

1 reference

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Caspase-2 and tau-a toxic partnership?

23 February 2021

1 reference

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Caspase-2 cleavage of tau reversibly impairs memory

23 February 2021

1 reference

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Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

23 February 2021

1 reference

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The Neuropathology of Huntington´s disease: classical findings, recent developments and correlation to functional neuroanatomy

23 February 2021

1 reference

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

23 February 2021

1 reference

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The role of tau in the pathological process and clinical expression of Huntington's disease

23 February 2021

1 reference

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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

23 February 2021

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Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.

23 February 2021

1 reference

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Mutant huntingtin alters Tau phosphorylation and subcellular distribution

23 February 2021

1 reference

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The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects

23 February 2021

1 reference

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Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

23 February 2021

1 reference

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Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

23 February 2021

1 reference

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Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

23 February 2021

1 reference

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Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice.

23 February 2021

1 reference

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Huntington's disease - neuropathology

23 February 2021

1 reference

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Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

23 February 2021

1 reference

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Association of corticobasal degeneration and Huntington's disease: can Tau aggregates protect Huntingtin toxicity?

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

23 February 2021

1 reference

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

23 February 2021

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23 February 2021

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

The biochemical mechanism of caspase-2 activation

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

A cell-based screen for drugs to treat Huntington's disease

23 February 2021

1 reference

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Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

23 February 2021

1 reference

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Rigid and akinetic forms of Huntington's chorea

23 February 2021

1 reference

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

23 February 2021

1 reference

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Juvenile onset Huntington's disease--clinical and research perspectives.

23 February 2021

1 reference

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

23 February 2021

1 reference

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

23 February 2021

1 reference

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

23 February 2021

1 reference

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Alzheimer-type lesions in Huntington's disease

23 February 2021

1 reference

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

23 February 2021

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

23 February 2021

1 reference

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CAG repeat number governs the development rate of pathology in Huntington's disease

23 February 2021

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

23 February 2021

1 reference

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The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

Late onset of Huntington's disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

Dementia of the Alzheimer's type and Huntington's disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

The coexistence and differentiation of late onset Huntington's disease and Alzheimer's disease. A case report and review of the literature

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

Huntington disease associated with Alzheimer disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6664763

10.1186/S40478-019-0764-9

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31358058%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

1 reference

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28 April 2020

1 reference