Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer (Q90654533)

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15 April 2020

title

Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer (English)

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15 April 2020

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Francesca Malentacchi

1

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15 April 2020

Irene Turrini

2

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Flavia Sorbi

3

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Elisabetta Projetto

4

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Francesca Castiglione

5

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Massimiliano Fambrini

6

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Felice Petraglia

7

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Serena Pillozzi

8

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Ivo Noci

9

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publication date

18 December 2018

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volume

41

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page(s)

1560-1574

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issue

3

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CTNNB1 mutations and beta-catenin expression in endometrial carcinomas

15 April 2020

cites work

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12 December 2020

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

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12 December 2020

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia

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12 December 2020

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.

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12 December 2020

PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters

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12 December 2020

PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences

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12 December 2020

High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer

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12 December 2020

Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.

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12 December 2020

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

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12 December 2020

High-resolution melting analysis (HRMA): more than just sequence variant screening.

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12 December 2020

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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12 December 2020

Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations

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12 December 2020

Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications

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12 December 2020

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

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12 December 2020

A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas

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12 December 2020

PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.

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12 December 2020

Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer-a clinical and pathological evaluation

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12 December 2020

Is high resolution melting analysis (HRMA) accurate for detection of human disease-associated mutations? A meta analysis

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12 December 2020

PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3'-kinase pathway alterations might be associated with favorable prognosis.

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12 December 2020

PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations

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12 December 2020

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing

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12 December 2020

New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes.

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12 December 2020

Use of mutation profiles to refine the classification of endometrial carcinomas.

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12 December 2020

Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas

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12 December 2020

Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative

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12 December 2020

Pharmacogenomics discovery and implementation in genome-wide association studies era

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12 December 2020

High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.

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12 December 2020

Molecular pathology of endometrial carcinoma

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12 December 2020

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression

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12 December 2020

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma

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12 December 2020

Endometrial cancer: molecular and therapeutic aspects

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12 December 2020

Integrated genomic characterization of endometrial carcinoma

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12 December 2020

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles

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12 December 2020

Carcinogenesis of PIK3CA.

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12 December 2020

Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).

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12 December 2020

Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomas

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12 December 2020

Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients.

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12 December 2020

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer

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12 December 2020

PIK3CA missense mutation is associated with unfavorable outcome in grade 3 endometrioid carcinoma but not in serous endometrial carcinoma.

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12 December 2020

Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF mutations

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12 December 2020

Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer.

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12 December 2020

Classification of endometrial carcinoma: more than two types

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12 December 2020

Immunohistochemical characterization of endometrial carcinomas: endometrioid, serous and clear cell adenocarcinomas in association with genetic analysis

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12 December 2020

PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas

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12 December 2020

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

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12 December 2020

Role of exon 7 PTEN Gene in Endometrial Carcinoma.

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12 December 2020

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12 December 2020

ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up

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12 December 2020

Improved survival associated with somatic PIK3CA mutations in copy-number low endometrioid endometrial adenocarcinoma

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12 December 2020

Expression of PTEN and β-Catenin and Their Relationship With Clinicopathological and Prognostic Factors in Endometrioid Type Endometrial Cancer

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12 December 2020

Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.

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12 December 2020

Effects of the multikinase inhibitors Sorafenib and Regorafenib in PTEN deficient neoplasias.

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12 December 2020

Landscape of Phosphatidylinositol-3-Kinase Pathway Alterations Across 19 784 Diverse Solid Tumors

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12 December 2020

Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer

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12 December 2020

Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas

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12 December 2020

Endometrioid endometrial adenocarcinoma: an increase of G3 cancers?

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12 December 2020

Detection of EGFR mutations in patients with non-small cell lung cancer by high resolution melting. Comparison with other methods.

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12 December 2020

Phase II basket trial of perifosine monotherapy for recurrent gynecologic cancer with or without PIK3CA mutations.

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12 December 2020

Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

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12 December 2020

PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.

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12 December 2020

High Resolution Melting Analysis for Rapid Detection of PIK3CA Gene Mutations in Bladder Cancer: A Mutated Target for Cancer Therapy.

1 reference

12 December 2020

Identifiers

DOI

10.3892/OR.2018.6939

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15 April 2020

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15 April 2020

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