Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme (Q90237059)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30010674%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

title

Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme (English)

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12 April 2020

8

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12 April 2020

Stefano Tiziani

21

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12 April 2020

Lauren I R Ehrlich

24

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12 April 2020

author name string

Todd A Triplett

1

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12 April 2020

Kendra C Garrison

2

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12 April 2020

Nicholas Marshall

3

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12 April 2020

Moses Donkor

4

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12 April 2020

John Blazeck

5

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12 April 2020

Candice Lamb

6

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12 April 2020

Ahlam Qerqez

7

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12 April 2020

Yuri Tanno

9

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12 April 2020

Wei-Cheng Lu

10

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12 April 2020

Christos S Karamitros

11

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12 April 2020

Kyle Ford

12

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12 April 2020

Bing Tan

13

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12 April 2020

Xiaoyan M Zhang

14

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12 April 2020

Karen McGovern

15

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12 April 2020

Silvia Coma

16

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12 April 2020

Yoichi Kumada

17

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12 April 2020

Mena S Yamany

18

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12 April 2020

Enrique Sentandreu

19

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12 April 2020

George Fromm

20

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12 April 2020

Taylor H Schreiber

22

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12 April 2020

Mark Manfredi

23

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12 April 2020

Everett Stone

25

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12 April 2020

George Georgiou

26

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12 April 2020

publication date

16 July 2018

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12 April 2020

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12 April 2020

volume

36

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12 April 2020

issue

8

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12 April 2020

page(s)

758-764

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Targeting the IDO1/TDO2-KYN-AhR Pathway for Cancer Immunotherapy - Challenges and Opportunities

12 April 2020

cites work

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7 January 2021

Discovery of IDO1 Inhibitors: From Bench to Bedside

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7 January 2021

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

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7 January 2021

The end of the road for the tryptophan depletion concept in pregnancy and infection

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7 January 2021

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

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7 January 2021

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

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7 January 2021

Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion

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7 January 2021

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers

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7 January 2021

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

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7 January 2021

Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells

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7 January 2021

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

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7 January 2021

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.

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7 January 2021

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

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7 January 2021

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment

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7 January 2021

IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice

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7 January 2021

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

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7 January 2021

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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7 January 2021

Trace Derivatives of Kynurenine Potently Activate the Aryl Hydrocarbon Receptor (AHR).

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7 January 2021

A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study

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7 January 2021

Kynurenines in the CNS: recent advances and new questions.

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7 January 2021

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

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Structure and mechanism of kynureninase.

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7 January 2021

Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy

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7 January 2021

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

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7 January 2021

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

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7 January 2021

A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

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7 January 2021

Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation

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7 January 2021

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.

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7 January 2021

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

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7 January 2021

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.

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7 January 2021

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

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7 January 2021

Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art

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7 January 2021

Possible roles of excess tryptophan metabolites in cancer

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7 January 2021

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.

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7 January 2021

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

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7 January 2021

Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

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7 January 2021

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

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Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens

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7 January 2021

Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

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CTLA-4 blockade in tumor models: an overview of preclinical and translational research

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30010674

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NBT.4180

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12 April 2020

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12 April 2020

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