Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes (Q89960154)

From Wikidata

Jump to navigation Jump to search

scientific article published on 27 February 2020

Language	Label	Description	Also known as
English	Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes	scientific article published on 27 February 2020

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

author name string

Wei Zhang

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Li Ma

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Mei Yang

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Jian Xu

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Zhipeng Lu

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Zhen Zhao

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Rong Chen

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Yang Chai

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Jian-Fu Chen

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

publication date

27 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Genes & Development

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

34

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

7-8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

580-597

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Rotorod sensorimotor learning in cerebellar mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in cell-cycle kinetics during the development and evolution of primate neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of brain overgrowth in the first year of life in autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT/PKB signaling: navigating downstream

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural stem and progenitor cells in cortical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioural phenotyping assays for mouse models of autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of neuropsychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new subtype of progenitor cell in the mouse embryonic neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron number and size in prefrontal cortex of children with autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic activation of AKT3 causes hemispheric developmental brain malformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autism genetics: searching for specificity and convergence

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cerebral cortex size and folding by expansion of basal progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conical expansion of the outer subventricular zone and the role of neocortical folding in evolution and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral organoids model human brain development and microcephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome engineering using the CRISPR-Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patches of disorganization in the neocortex of children with autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longitudinal changes in cortical thickness in autism and typical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic dysregulation in a human iPS cell model of mental disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular identity of human outer radial glia during cortical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head circumference and brain size in autism spectrum disorder: A systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Expansion and Folding in Human Cerebral Organoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early brain development in infants at high risk for autism spectrum disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell diversity and network dynamics in photosensitive human brain organoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline Chd8 haploinsufficiency alters brain development in mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI3K Pathway in Human Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked Parkinsonism with Intellectual Disability caused by novel mutations and somatic mosaicism in RAB39B gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of brain organoids to investigate neural development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward a conceptual framework for early brain and behavior development in autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in RAB39B in individuals with intellectual disability, autism spectrum disorder, and macrocephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal mTOR Activation in Autism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ASD Living Biology: from cell proliferation to clinical phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32115408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.332494.119

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32115408%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q89960154&oldid=1936043260"