Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion (Q89787729)

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8 April 2020

title

Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion (English)

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evasion of host immune response

8 April 2020

main subject

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Simone Joas

1

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8 April 2020

Ulrike Sauermann

2

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8 April 2020

Berit Roshani

3

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8 April 2020

Antonina Klippert

4

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Maria Daskalaki

5

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Kerstin Mätz-Rensing

6

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Nicole Stolte-Leeb

7

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Anke Heigele

8

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Gregory K Tharp

9

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Prachi Mehrotra Gupta

10

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Sydney Nelson

11

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Steven Bosinger

12

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Laura Parodi

13

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Luis Giavedoni

14

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Guido Silvestri

15

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Daniel Sauter

16

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Christiane Stahl-Hennig

17

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Frank Kirchhoff

18

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8 April 2020

publication date

1 February 2020

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8 April 2020

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8 April 2020

volume

30

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issue

7

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8 April 2020

page(s)

2261-2274.e7

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describes a project that uses

8 April 2020

DESeq2

object named as

DESeq2

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

1 reference

12 December 2020

Immunization with Tween-ether-treated SIV adsorbed onto aluminum hydroxide protects monkeys against experimental SIV infection

1 reference

12 December 2020

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

12 December 2020

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system

1 reference

12 December 2020

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

1 reference

12 December 2020

Reduced rate of disease development after HIV-2 infection as compared to HIV-1

1 reference

12 December 2020

Insufficient inactivation of HIV-1 in human cryo poor plasma by beta-propiolactone: results from a highly accurate virus detection method

1 reference

12 December 2020

Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus

1 reference

12 December 2020

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

12 December 2020

Env-independent protection induced by live, attenuated simian immunodeficiency virus vaccines

1 reference

12 December 2020

Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

1 reference

12 December 2020

Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1.

1 reference

12 December 2020

The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.

1 reference

12 December 2020

SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques

1 reference

12 December 2020

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

1 reference

12 December 2020

Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques

1 reference

12 December 2020

The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs

1 reference

12 December 2020

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

1 reference

12 December 2020

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

1 reference

12 December 2020

Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

1 reference

12 December 2020

Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes

1 reference

12 December 2020

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques

1 reference

12 December 2020

Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus

1 reference

12 December 2020

Simultaneous detection of multiple cytokines and chemokines from nonhuman primates using luminex technology.

1 reference

12 December 2020

Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement

1 reference

12 December 2020

Reduction of viral loads by multigenic DNA priming and adenovirus boosting in the SIVmac-macaque model

1 reference

12 December 2020

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques

1 reference

12 December 2020

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

1 reference

12 December 2020

Sustained conservation of CD4+ T cells in multiprotein triple modality-immunized rhesus macaques after intrarectal challenge with simian immunodeficiency virus

1 reference

12 December 2020

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor

1 reference

12 December 2020

Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

1 reference

12 December 2020

Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques

1 reference

12 December 2020

Viral modulation of T-cell receptor signaling

1 reference

12 December 2020

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection

1 reference

12 December 2020

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

1 reference

12 December 2020

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

1 reference

12 December 2020

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

1 reference

12 December 2020

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

1 reference

12 December 2020

Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression

1 reference

12 December 2020

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

1 reference

12 December 2020

Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragments

1 reference

12 December 2020

The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses

1 reference

12 December 2020

Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression

1 reference

12 December 2020

One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.

1 reference

12 December 2020

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

1 reference

12 December 2020

Natural SIV hosts: showing AIDS the door

1 reference

12 December 2020

STAR: ultrafast universal RNA-seq aligner

1 reference

12 December 2020

Nonhuman primate models in AIDS research

1 reference

12 December 2020

Link between primate lentiviral coreceptor usage and Nef function

1 reference

12 December 2020

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals

1 reference

12 December 2020

HTSeq--a Python framework to work with high-throughput sequencing data

1 reference

12 December 2020

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.

1 reference

12 December 2020

Lentiviral Nef proteins manipulate T cells in a subset-specific manner

1 reference

12 December 2020

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

1 reference

12 December 2020

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins

1 reference

12 December 2020

Residual inflammation and viral reservoirs: alliance against an HIV cure

1 reference

12 December 2020

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

1 reference

12 December 2020

Rapid and Slow Progressors Show Increased IL-6 and IL-10 Levels in the Pre-AIDS Stage of HIV Infection

1 reference

12 December 2020

Non-human primates in HIV research: Achievements, limits and alternatives

1 reference

12 December 2020

Interferons and HIV Infection: The Good, the Bad, and the Ugly

1 reference

12 December 2020

Phyloepidemiological Analysis Reveals that Viral Divergence Led to the Paucity of Simian Immunodeficiency Virus SIVmus/gsn/mon Infections in Wild Populations

1 reference

12 December 2020

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

1 reference

12 December 2020

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

1 reference

12 December 2020

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

1 reference

12 December 2020

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.

1 reference

12 December 2020

Vector order determines protection against pathogenic simian immunodeficiency virus infection in a triple component vaccine by balancing CD4+ and CD8+ T-cell responses

1 reference

12 December 2020

Pentraxin-3 regulates the inflammatory activity of macrophages

1 reference

12 December 2020

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host

1 reference

12 December 2020

Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins.

1 reference

12 December 2020

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.

1 reference

12 December 2020

Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δ-Infected Animals

1 reference

12 December 2020

Advances and challenges in targeting IRF5, a key regulator of inflammation

1 reference

12 December 2020

Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection

1 reference

12 December 2020

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

1 reference

12 December 2020

10.1016/J.CELREP.2020.01.069

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32075764%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32075764%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

32075764

1 reference