α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment (Q89654680)

From Wikidata

Jump to navigation Jump to search

scientific article published on 24 February 2020

Language	Label	Description	Also known as
English	α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment	scientific article published on 24 February 2020

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

based on heuristic

inferred from title

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Rolf Hilgenfeld

14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

8

object named as

Pieter Leyssen

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

12

object named as

Eric J Snijder

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

3

object named as

Yuri Kusov

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

9

object named as

Kristina Lanko

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

2

object named as

Daizong Lin

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

4

object named as

Yong Nian

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Albrecht von Brunn

7

object named as

Albrecht von Brunn

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

author name string

Linlin Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Qingjun Ma

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Jiang Wang

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Adriaan de Wilde

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

publication date

24 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new virus isolated from the human respiratory tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth of human hepatoma cells lines with differentiated functions in chemically defined medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new human coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bio

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular replacement with MOLREP

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Features and development of Coot

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of the CCP4 suite and current developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An introduction to data reduction: space-group determination, scaling and intensity statistics

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The differential clinical impact of human coronavirus species in children with cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JLigand: a graphical tool for the CCP4 template-restraint library

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hand, foot, and mouth disease in China, 2008-12: an epidemiological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intricacies of cardiac damage in coxsackievirus B3 infection: implications for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterovirus d68. A focused review and clinical highlights from the 2014 U.S. Outbreak

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

South Korean MERS outbreak spotlights lack of research

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhinovirus-induced asthma exacerbations and risk populations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN-alpha in a patient with newly diagnosed ALL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/32045235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.9B01828

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Dimensions Publication ID

1 reference

Dimensions COVID-19 publications, datasets and clinical trials

10.6084/M9.FIGSHARE.11961063

28 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32045235%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q89654680&oldid=1742850845"